PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Czasopismo
2015 | 1 | 1 |
Tytuł artykułu

Mesoporous bioactive glasses: Relevance of their porous structure compared to that of classical bioglasses

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In the last decade, the development of third generation bioceramics for Bone Tissue Regeneration has experienced significant progress with the emergence of a new generation of nanostructured materials named mesoporous bioactive glasses (MBG). This new generation of materials, also known as “templated glasses”, presents chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. This article shows an indepth comparative study of the ordered porous structures of MBGs compared to conventional glasses (melt and solgel) andhowthese properties influence the bioactivity process. Moreover, the possibility to tailor the textural and structural properties of these nanostructured materials by an exhaustive control of the different synthesis parameters is also discussed. A brief overview regarding the possibility of using these materials as controlled drug delivery systems and as starting materials for the fabrication of 3D scaffolds for bone tissue regeneration is also given.
Wydawca
Czasopismo
Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
otrzymano
2015-09-09
zaakceptowano
2015-09-09
online
2015-11-03
Twórcy
  • Departamento de
    Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM,
    Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12,
    28040-Madrid, Spain; Centro de Investigación Biomédica en Red.
    Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Spain;
  • Departamento de
    Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM,
    Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12,
    28040-Madrid, Spain; Centro de Investigación Biomédica en Red.
    Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Spain;
Bibliografia
  • [1] Hench L.L., Splinter R.J., Greenlee T.K., Allen W.C., Bondingmechanisms at the interface of ceramic prosthetic materials, J.Biomed. Mater. Res. 1971, 2, 117–141.[Crossref]
  • [2] Hench L.L., Polak J.M., Third-generation biomedical materials,Science 2002, 295, 1014–1017.
  • [3] Jones J.J., Review of Bioactive Glass: From Hench to Hybrids,Acta Biomater. 2013, 9, 4457–4486.[Crossref]
  • [4] Li R., Clark A.E., Hench L.L., An Investigation of Bioactive GlassPowders by Sol-Gel Processing, J. Appl. Biomater. 1991, 2, 231–239.[Crossref]
  • [5] Vallet-Regí M., Ceramics for medical applications, J. Chem. Soc.Dalton Trans. 2001, 2, 97–108.[Crossref]
  • [6] Salinas A.J., Vallet-Regí M., Evolution of ceramics with medicalapplications, Z. Anorg. Allg. Chem. 2007, 633, 1762–1773.
  • [7] Vallet-Regí M., Ragel C.V., Salinas A.J., Glasses with medical applications,Eur. J. Inorg. Chem. 2003, 1029–1042.[Crossref]
  • [8] Balas F., Arcos D., Pérez-Pariente J., Vallet-Regí M., Texturalproperties of SiO2-CaO-P2O5 glasses prepared by the sol–gelmethod, J. Mater. Res. 2001, 16, 1345–1348.
  • [9] Salinas A.J., Vallet-Regí M., Izquierdo-Barba I., Biomimetic apatitedeposition on calcium silicate gel glasses, J. Sol-Gel Sci.Technol. 2001, 21, 13–25.
  • [10] Arcos D., Vallet-Regí M., Sol-gel silica based biomaterials andbone tissue regeneration, Acta Biomater 2010, 6, 2874–2888.[Crossref]
  • [11] Mahony O., Jones J.R., Porous bioactive nanostructured scaffoldsfor bone regeneration: a sol-gel solution, Nanomedicine2008, 3, 233–245.[Crossref]
  • [12] Coradin T., Boissière M., Livage J., Sol-gel chemistry in medicinalscience, Curr. Med. Chem. 2006, 13, 99–108.[Crossref]
  • [13] Hoppe A., Guldal N.S., Boccaccini A.R., A review of the biologicalresponse to ionic dissolution products from bioactive glassesand glass-ceramics, Biomaterials 2011, 32, 2757–2774.[Crossref]
  • [14] Salinas A.J., Vallet-Regí M., Surface Tailoring of Inorganic Materialsfor Biomedical Applications, Ed. Raimondi L., Bianchi C.,and Verné E., Bentham Science Publishers (2012), ISBN: 978-1-60805-462-6,
  • [15] Vallet-Regi M., Nanostructured Mesoporous Silica Matrices inNanomedicine, J. Intern. Med. 2010, 267, 22–43.
  • [16] Izquierdo-Barba I., Salinas A.J., Vallet-Regí M., BioactiveGlasses: From Macro to Nano, International Journal of AppliedGlass Science 2013, 1–13.
  • [17] Vallet-Regí M., Revisiting ceramics for medical application, DaltonTrans 2006, 44, 5211–5220.[Crossref]
  • [18] Yanagisawa T., Shimizu T., Kuroda K., Kato C., The preparationof alkyltrimethylammonium-kanemite complexes and their conversionto microporous materials, Bull. Chem. Soc. Jpn. 1990,63, 988–992.[Crossref]
  • [19] Kresge C.T., Leonowicz M.E., Roth W.J., Vartuli J.C., Beck J.S.,Ordered mesoporous molecular sieves synthesized by a liquidcrystaltemplate mechanism, Nature 1992, 359, 710–712.
  • [20] Inagaki S., Fukushima Y., Kuroda K.J., Synthesis of highly orderedmesoporous materials from a layered polysilicate, J.Chem. Soc., Chem. Commun. 1993, 680–683.[Crossref]
  • [21] Taguchi A., Schuth F., Ordered mesoporous materials in catalysis.Micro. Meso. Mater. 2005, 77, 1–45.[Crossref]
  • [22] Zhao D., Feng J., Huo Q., Melosh N., Fredickson G.H., ChmelkaB.F., et al., Triblock copolymer syntheses of mesoporous silicawith periodic 50 to 300 angstrom pores, Science 1998, 279,548–552.
  • [23] Corma A., From microporous to mesoporous molecular sievematerials and their use in catalysis, Chem. Rev. 1997, 97, 2373–2419.[Crossref]
  • [24] Vallet-Regí M., Rámila A., del Real R.P., Pérez-Pariente J., A newproperty of MCM-41: drug delivery system, Chem. Mater. 2001,13, 308–311.[Crossref]
  • [25] Manzano M., Colilla M., Vallet-Regí M., Drug delivery from orderedmesoporous matrices, Expert Opin. Drug Deliv. 2009, 6,1383–1400.[Crossref]
  • [26] Vallet-Regí M., Ordered mesoporous materials in the context ofdrug delivery systems and bone tissue engineering, Chem. Eur.J. 2006, 12, 5934–5943.[Crossref]
  • [27] Vallet-Regí M., Ruiz-Hernández E., Bioceramics: from bone regenerationto cancer nanomedicine, Adv.Mater. 2011, 23, 5177–5218.[Crossref]
  • [28] Vallet-Regí M., Balas F., Arcos D., Mesoporousmaterials for drugdelivery, Angew. Chem. Int. Ed. 2007, 46, 7548–7558.[Crossref]
  • [29] Slowing I.I., Trewyn B.G., Giri S., Lin V.S.Y., Mesoporous silicananoparticles for drug delivery and biosensing applications,Adv. Funct. Mater. 2007, 17, 1225–1236.[Crossref]
  • [30] Wang S., Ordered mesoporous materials for drug delivery, Micro.Meso. Mater. 2009, 117, 1–9.
  • [31] Manzano M., Vallet-Regí M., New developments in orderedmesoporous materials for drug delivery, J. Mater. Chem. 2010,20, 5593–5604.[Crossref]
  • [32] Baeza A., Colilla M., Vallet-Regí M., Advances in mesoporous silicananoparticles for targeted stimuli-responsive drug delivery,Expert Opin. Drug Deliver., Doi: 10.1517/17425247.2014.953051[Crossref]
  • [33] Tan K., Cheang P., Ho I.A.W., Lam P.Y.P., Hui K.M., Nanosized bioceramicparticles could function as eflcient gene delivery vehicleswith target specificity for the spleen, Gene Therapy 2007,14, 828–835.[Crossref]
  • [34] Slowing I.I., Trewyn B.G., Lin V.S.Y., Effect of surface functionalizationof MCM-41-type mesoporous silica nanoparticles onthe endocytosis by human cancer cells, J. Am. Chem. Soc. 2006,128, 14792–14793.[Crossref]
  • [35] Hernandez R., Tseng H.R., Wong J.W., Stoddart J.F., Zink J.I., Anoperational supramolecular nanovalve, J. Am. Chem. Soc. 2004,126, 3370–3371.[Crossref]
  • [36] Ferris D.P., Zhao Y.L., Khashab N.M., Khatib H.A., StoddartJ.F., Zink J.I., Light-operated mechanized nanoparticles, J. Am.Chem. Soc. 2009, 131, 1686–1688.
  • [37] Ruiz-Hernández E., Baeza A., Vallet-Regí M., Smart drug deliverythrough DNA/magnetic nanoparticle gates, ACSNano 2011,5, 1259–1266.
  • [38] Vallet-Regí M., Ruiz-González L., Izquierdo-Barba I., Gonzalez-Calbet J.M., Revisiting silica based ordered mesoporous materials:medical applications, J. Mater. Chem. 2006, 16, 26–31.[Crossref]
  • [39] Izquierdo-Barba I., Ruiz-González L., Doadrio J.C., González-Calbet J.M., Vallet-Regí M., Tissue regeneration: a new propertyof mesoporous materials, Solid State Sci. 2005, 7, 983–989.[Crossref]
  • [40] Li P., Ohtsuki C., Kokubo T., Nankanishi K., Soga N., NakamuraT., et al., Apatite formation induced by silica gel in a simulatedbody fluid, J. Am. Ceram. Soc. 1992, 75, 2091–2097.
  • [41] Li P., Ohtsuki C., Kokubo T., Nankanishi K., Soga N., NakamuraT., et al., Effects of ions in aqueous media on hydroxyapatite inductionby silica gel and its relevance to bioactivity of bioactiveglass and glass-ceramics, J. Appl. Biomat. 1993, 4, 221–229.[Crossref]
  • [42] Pereira M.M., Clark A.E., Hench L.L., Effect of texture on the rateof hydroxyapatite formation on silica gel surface, J. Am. Ceram.Soc. 1995, 78, 2463–2468.[Crossref]
  • [43] Vallet-Regí M., Izquierdo-Barba I., Colilla M., Structure and functionalizationof mesoporous bioceramics for bone tissue regeneration,and local drug delivery, Phil. Trans. R. Soc. A 2012, 370,1400–1421.
  • [44] Yan X.X., Yu C.Z., Zhou X.F., Tang J.W., Zhao D.Y., Highly orderedmesoporous bioactive glasses with superior in vitro bone formingbioactivities, Angew. Chem. Int. Ed. 2004, 43, 5980–5984.[Crossref]
  • [45] López-Noriega A., Arcos D., Izquierdo-Barba I., Sakamoto Y.,Terasaki O., Vallet-Regí M., Ordered mesoporous bioactiveglasses for bone tissue regeneration, Chem. Mater. 2006, 18,3137–3144.[Crossref]
  • [46] Brinker C.J., Lu Y.F., Sellinger A., Fan H.Y., Evaporation-inducedself-assembly: nanostructuresmade easy, Adv.Mater. 1999, 11,579–601.[Crossref]
  • [47] Zhong J., Greenspan D.C., Processing and properties of sol-gelbioactive glasses, J. BiomedMater Res Appl Biomater. 2000, 53,694–701.[Crossref]
  • [48] Yan X.X., Deng H.X., Huang X.H., Lu G.Q., Qiao S.Z., Zhao D.Y.,et al., Mesoporous bioactive glasses. I. Synthesis and structuralcharacterization, J. Non-Cryst. Solids 2005, 351, 3209–3217.
  • [49] Yan X.X., Huang X.H., Yu C.Z., Deng H.X., Wang Y., Zhang A.D.,et al., The in vitro bioactivity of mesoporous bioactive glasses,Biomaterials 2006, 27, 3396–3403.[Crossref]
  • [50] Yun H.S., Kim S.E., Hyeon Y.T., Highly ordered mesoporousbioactive glasses with Im3m symmetry, Matter Lett. 2007, 61,4569–4572.
  • [51] Yun H.S., Kim S.E., Hyeon Y.T., Preparation of 3 dimensionalcubic ordered mesoporous bioactive glasses, Solid State Sci.2008, 10, 1083–1092.
  • [52] Kaneda M., Tsubakiyama T., Carlsson A., Sakamoto Y., OshunaT., Terasaki O., et al., Structural study of mesoporous MCM-48and carbon networks synthesized in the spaces of MCM-48 byelectron crystallography, J. Phys. Chem. B 2002, 106, 125.
  • [53] García A., Cicuéndez M., Izquierdo-Barba I., Arcos D., Vallet-Regí M., Essential role of calcium phosphate heterogeneities in2D-hexagonal and 3D-cubic SiO2-CaO-P2O5 mesoporous bioactiveglasses, Chem. Mater. 2009, 21, 5474–5484.[Crossref]
  • [54] Li Z., Chen D.H., Tu B., Zhao D.Y., Synthesis and phase behaviorsof bicontinuous cubic mesoporous silica from triblock copolymermixed anionic surfactant, Microporous Mesoporous Mater.2007, 105, 34–40.
  • [55] Izquierdo-Barba I., Vallet-Regí M., Fascinating properties ofbioactive template glasses: a new generation of nanostructuredbioceramics, Solid State Sci. 2011, 13, 773–783.[Crossref]
  • [56] Izquierdo-Barba I., Arcos D., Sakamoto Y., Terasaki O., López-Noriega A., Vallet-Regí M., High-performance mesoporous bioceramicsmimicking bone mineralization, Chem. Mater. 2008,20, 3191–3198.[Crossref]
  • [57] Gunawidjaja P., Mathew R., Lo A.Y.H., Izquierdo-Barba I., GarcíaA., Arcos D., et al., Local Structures of Mesoporous BioactiveGlasses and Their Surface Alterations in Vitro: Inferences FromSolid-State Nuclear Magnetic Resonance, Phil. Trans. R. Soc. A2012, 370 1376–1399.
  • [58] Lin K.S.K., Tseng Y.H., Mou Y., Hsu Y.C., Yang C.M., Chan J.C.C.,Mechanistic Study of Apatite Formation on Bioactive Glass SurfaceUsing 31P Solid-State NMR Spectroscopy, Chem. Mater.2005, 17 4493–4501.[Crossref]
  • [59] Clark A.E., Pantano C.G., Hench L.L., Auger Spectroscopic Analysisof Bioglass Corrosion Films, J. Am. Ceram. Soc. 1976, 5937–39 [Crossref]
  • [1976].
  • [60] Leonova E., Izquierdo-Barba I., Arcos D., Lopez-Noriega A.,Hedin N., Vallet-Regí M., et al., Multinuclear Solid-State NMRStudies of Ordered Mesoporous Bioactive Glasses, J. Phys.Chem. C 2008, 112, 5552–5562.[Crossref]
  • [61] Maciel G.E., Sindorf D.W., Silicon-29 Nuclear Magnetic Resonancestudy of the surface of silica-gel by cross polarization andmagic-angle spinning, J. Am. Chem. Soc. 1980, 102 7606–7607.
  • [62] Elgayar I., Aliev A.E., Boccaccini A.R., Hill R.G., Structural Analysisof Bioactive Glasses, J. Non-Cryst. Solids 2005, 351, 173–183.
  • [63] Pedone A., Properties Calculations of Silica-Based Glasses byAtomistic Simulations Techniques: A Review, J. Phys. Chem. C2009, 113, 773–784.
  • [64] Tilocca A., Cormack A.N., Surface Signatures of Bioactivity: MDSimulations of 45S and 65S Silicate Glasses, Langmuir 2010,26, 545–551.[Crossref]
  • [65] Tilocca A., Structural Models of Bioactive Glasses from MolecularDynamics Simulations, Proc. R. Soc. A 2009, 465 1003–1027.
  • [66] Vallet-Regí M., Salinas A.J., Ramírez-Castellanos J., González-Calbet J.M., Nanostructure of Bioactive Sol-Gel Glasses andOrganic-Inorganic Hybrids, Chem. Mater. 2009, 17, 1874–1879.
  • [67] Mathew R., Turdean-Ionescu C., Stevensson B., Izquierdo-BarbaI., García A., Arcos D., et al., Direct Probing of the Phosphate-IonDistribution in Bioactive Silicate Glasses by Solid-State NMR:Evidence for Transitions between Random/Clustered Scenarios,Chem. Mater. 2013, 25, 1877–1885[Crossref]
  • [68] Xia W., Chang J., Well-ordered mesoporous bioactive glasses(MBG): A promising bioactive drug delivery system, J. ControlRel. 2006, 110, 522–530.[Crossref]
  • [69] Xia W., Chang J., Preparation, in vitro bioactivity and drug releaseproperty of well-ordered mesoporous 58S bioactive glass,J. Non-Cryst. Solids 2008, 354, 1338–1341.
  • [70] Zhao L.Z., Yan X.X., Zhou X.F., Zhou L., Wang H.N., Tang J.W., etal., Mesoporous bioactive glasses for controlled drug release,Microporous Mesoporous Mater 2008, 109, 210–215.
  • [71] Cicuéndez M., Izquierdo-Barba I., Portolés M.T., Vallet-Regí M.,Biocompatibility and levofloxacin delivery of mesoporous materials,Eur. J. Pharm. Biopharm. 2013, 84, 115–124.[Crossref]
  • [72] Zhao Y.F., Loo S.C.J., Chen Y.Z., Boey F.Y.C., Ma J., In situ SAXRDstudy of sol–gel induced well-ordered mesoporous bioglassesfor drug delivery, J. Biomed.Mater. Res. 2008, 85A, 1032–1042.[Crossref]
  • [73] Sun J., Li Y.S., Li L., Zhao W.R., Li L., Gao J.H., et al., Functionalizationand bioactivity in vitro of mesoporous bioactive glasses,J. Non-Cryst. Solids 2008, 354, 3799–3805.
  • [74] López-Noriega A., Arcos D., Vallet-Regí M., FunctionalizingMesoporous Bioglasses for Long-Term Anti-Osteoporotic DrugDelivery, Chem. Eur. J. 2010, 16, 10879–10886.[Crossref]
  • [75] Wu C., Chang J., Multifunctional mesoporous bioactive glassesfor effective delivery of therapeutic ions and drug/growth factors,J. Control Release 2014, 193, 282–295.[Crossref]
  • [76] Ostomel T.A., Shi Q.H., Tsung C.K., Liang H.J., Stucky G.D.,Spherical Bioactive Glass with Enhanced Rates of HydroxyapatiteDeposition and Hemostatic Activity, Small 2006, 2, 1261–1265.[Crossref]
  • [77] Arcos D., López-Noriega A., Ruiz-Hernández E., Terasaki O.,Vallet-Regí M., Ordered mesoporous microspheres for bonegrafting and drug delivery, Chem. Mater. 2009, 21, 1000–1009.[Crossref]
  • [78] Yun H.-S., Kim S.-H., Lee S.Y., Song I.-H., Synthesis of high surfacearea mesoporous bioactive glass nanospheres,Mater Lett.2010, 64, 1850–1853.[Crossref]
  • [79] Zhao S., Li Y.B., Li D.X., Synthesis and in vitro bioactivity ofCaO-SiO2-P2O5 mesoporous microspheres, Microporous MesoporousMater. 2010, 135, 67–73.
  • [80] Hong Y.L., Chen X.S., Jing X.B., Fan H.S., Gu Z.W., Zhang X.D.,Fabrication and Drug Delivery of Ultrathin Mesoporous BioactiveGlass Hollow Fibers. Adv. Funct. Mater. 2010, 20, 1503–1510.[Crossref]
  • [81] Arcos D., Vallet-Regí M., Bioceramics for drug delivery, ActaMaterialia2013, 61, 890–911.
  • [82] Li X., Wang X.P., Hua Z., Shi J.L., One-pot synthesis of magneticand mesoporous bioactive glass composites and their sustaineddrug release property, Acta Materialia. 2008, 56, 3260–3265[Crossref]
  • [83] Lin H.-M., Wang W.-K., Hsiung P.-A., Shyu, S.-G., Light-sensitiveintelligent drug delivery systems of coumarin-modified mesoporousbioactive glass, Acta Biomaterialia 2010, 6, 3265–3263.
  • [84] Hutmacher D.W., Polymeric Scaffolds in Tissue EngineeringBone and Cartilage, Biomaterials 2000, 21, 2529–2543.[Crossref]
  • [85] Stevens M.M., George J., Exploring and Engineering the Cell SurfaceInterface, Science. 2005, 310, 1135–1138.
  • [86] Cicuendez M., Malmsten M., Doadrio J.C., Portoles M.T.,Izquierdo-Barba I., Vallet-Regi M., Tailoring hierarchical mesomacroporous3D scaffolds: from nano to macro, J. Mater. ChemB 2014, 2, 49–58.[Crossref]
  • [87] Shi Q.H.,Wang J.F., Zhang J.P., Fan J., Stucky G.D., Rapid-setting,mesoporous, bioactive glass cements that induce acceleratedin vitro apatite formation, Adv. Mater. 2006, 18, 1038–1042.[Crossref]
  • [88] Yun H.-S., Kim S.-E., Hyeon Y.-T., Design and preparationof bioactive glasses with hierarchical pore networks, Chem.Comm. 2007, 2139–2141.[Crossref]
  • [89] Arcos D., Vila M., López-Noriega A., Rossignol F., Champion E.,Oliveira F.J., Vallet-Regí M., Mesoporous bioactive glasses: mechanicalreinforcement by means of a biomimetic process, ActaBiomater 2011, 7, 2952–2959.[Crossref]
  • [90] Shruti S., Salinas A.J., Lusvardi G., Malavasi G., Menabue L.,Vallet-Regi M., Mesoporous bioactive scaffolds prepared withcerium-, gallium- and zinc-containing glasses, Acta Biomater2013, 9, 4836–4844.[Crossref]
  • [91] Yun H.-S., Kim S.-E., Hyun Y.-T., Heo S.-J., Shin J.-W., Three-Dimensional Mesoporous-Giantporous Inorganic/OrganicComposite Scaffolds for Tissue Engineering, Chem. Mater.2007, 19, 6363–6366.[Crossref]
  • [92] Yun H.-S., Kim S.-E., Hyun Y.-T., Heo S.-J., Shin J.-W., Hierarchicallymesoporous-macroporous bioactive glasses scaffolds forbone tissue regeneration, J Biomed Mater Res Part B: Appl Biomater2008, 87B, 374–380.[Crossref]
  • [93] Wang X.P., Li X., Onuma K., Ito A., Sogo Y., Kosuge K., et al.,Mesoporous bioactive glass coatings on stainless steel for enhancedcell activity, cytoskeletal organization and AsMg immobilization,J Mater Chem 2010, 20, 6437–6445.[Crossref]
  • [94] Alcaide M., Portolés P., López-Noriega A., Arcos D., Vallet-Regí M., Portolés M.T., Interaction of an ordered mesoporousbioactive glass with osteoblasts, fibroblasts and lymphocytesdemonstrates its biocompatibility as a potential bone graft material,Acta Biomater 2010, 6, 892–899.[Crossref]
  • [95] Zhu Y.F., Wu C.T., Ramaswamy Y., Kockrick E., Simon P., KaskelS., et al., Preparation, characterization and in vitro bioactivity ofmesoporous bioactive glasses (MBGs) scaffolds for bone tissueengineering, Micro Mesoporous Mater. 2008, 112, 494–503.
  • [96] Shih C.J., Chen H.T., Huang L.F., Lu P.S., Chang H.F., Chang I.L.,Synthesis andin vitro bioactivity of mesoporous bioactive glassscaffolds, Mater. Sci Eng. C 2010, 30, 657–663.[Crossref]
  • [97] Wei G.F., Yan X.X., Yi J., Zhao L.Z., Zhou L., Wang Y.H., etal., Synthesis and in-vitro bioactivity of mesoporous bioactiveglasses with tunable macropores. Microporous MesoporousMater. 2011, 143, 157–165.
  • [98] Zhu Y.F., Kaskel S., Comparison of the in vitro bioactivityand drug release property of mesoporous bioactive glasses(MBGs) and bioactive glasses (BGs) scaffolds, MicroporousMesoporous Mater 2009, 118, 176–182.
  • [99] Wu C.T., FanW., Gelinsky M., Xiao Y., Simon P., Schulze R., et al.,Bioactive SrO-SiO2 glass with well-ordered mesopores: Characterization,physiochemistry and biological properties, Acta Biomater2011, 7, 1797–1806.[Crossref]
  • [100] Arcos D., Boccaccini A.R., Bohner M., Diez-Perez A., Epple M.,Gomez- Barrena E., et al., The relevance of biomaterials to theprevention and treatment of osteoporosis, Acta Biomaterialia2014, 10, 1793–1805.[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_bglass-2015-0014
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.