"Imageable" Zinc-Silicate Glass Microspheres For Transarterial Embolization: A Renal Artery Embolization Study.

• Autorzy: Sharon Kehoe , Salma Amensag , Mark Looney , Robert J. Abraham , Daniel Boyd
• Języki publikacji: EN

Abstrakty

EN

Intrinsically radiopaque (imageable) microspheres for transarterial embolization (TAE) are required to enable real-time intraprocedural feedback and definition of spatial distribution patterns of embolic materials in target tissues. This pilot study evaluates acute and sub-chronic safety and efficacy of imageable zinc-silicate (Zn-Si) glass microspheres in a swine renal artery embolization (RAE) model. Eight swine were divided into two cohorts. Clinical determinants of embolization effectiveness, including imageability, deliverability and temporal/ spatial distribution of microspheres in target tissues were assessed. Subsequently, cohort I and II were used to evaluate the acute and subchronic host response against the Zn-Si microspheres versus a clinical control. The developed microspheres provide for direct intraprocedural feedback using standard diagnostic imaging techniques. Fluoroscopy correlated with ex-vivo high-resolution radiography, CT and micro-CT, demonstrating high imageability, excellent spatial distribution and packing of the Zn- Si microspheres. At follow-up, infarction of the embolized kidneys was noted without any major adverse tissue reaction. Mild recanalization was observed microscopically for both experimental and control microspheres. Zn-Si microspheres permit the definition of spatial distribution in a target tissue, consequently permitting the optimization, personalization and improvement of TAE techniques.

Słowa kluczowe

EN

Zinc-Silicate Glass; Embolic Microspheres; Radiopacity; Embolization; Swine Renal Artery Embolization; Biocompatibility

• Czasopismo: Biomedical glasses
• Rocznik: 2015
• Tom: 1
• Numer: 1

Daty

otrzymano

2015-06-08

zaakceptowano

2015-06-08

online

2015-08-26

Twórcy

autor

Sharon Kehoe

autor

Salma Amensag

autor

Mark Looney

autor

Robert J. Abraham

autor

Daniel Boyd

Bibliografia

• [1] Baino F., Novajra G., Miguez-Pacheo V., Boccaccini A.R., Vitale-Brovarone C., Bioactive Glasses: Special Applications outsidethe Skeletal System, J. Non. Cryst. Sol. 2015, XXX, XXX-XXX
• [2] Laurent A., Microspheres and Nonspherical Particles for Embolization,Techn. Vasc. and Inter. Radiol. 2007, 10, 248-256
• [3] Ryu R., Uterine Artery Embolization: Current Implications of EmbolicAgent Choice, J. Vasc. Inter. Radiol. 2005, 16, 1419-1422[Crossref]
• [4] Sharma K.V., Dreher M.R., Tang Y., Pritchard W.F., Chiesa O.A.,Karanian J., et al., Development of “Imageable” Beads for TranscatheterEmbolotherapy, J. Vasc. Interv. Radiol. 2010, 21, 865–876[Crossref]
• [5] Dreher M.R., Sharma K.V., Woods D.L., Reddy G., Tang Y.,Pritchard W.F., et al., Radiopaque Drug-Eluting Beads for TranscatheterEmbolotherapy: Experimental Study of Drug Penetrationand Coverage in Swine, J. Vasc. Interv. Radiol. 2012, 23,257–264[Crossref][WoS]
• [6] Lu X.J., Zhang Y., Cui D.C., Meng W.J., Du L.R., Guan H.T., et al.,Research of Novel Biocompatible Radiopaque Microcapsulesfor Arterial Embolization, Int. J. Pharm. 2013, 452, 211-219[WoS]
• [7] Stampfl S., Stampfl U., Bellemann N., Sommer C.M., ThierjungH., Radeleff B., et al., Biocompatibility and Recanalization Characteristicsof Hydrogel Microspheres with Polyzene-F as PolymerCoating, Cardiovasc. Interv. Radiol. 2008, 31, 799–806[WoS]
• [8] Siskin G.P., Dowling K., Virmani R., Jones R., Todd D., PathologicEvaluation of a Spherical Polyvinyl Alcohol Embolic Agent in aPorcine Renal Model, J. Vasc. Interv. Radiol. 2003, 14, 89–98[Crossref]
• [9] Spies J.B. Uterine Artery Embolization for Fibroids: Understandingthe Technical Causes of Failure, J. Vasc. Interv. Radiol. 2003,14, 11–14[Crossref]
• [10] Lopera G., Embolization in Trauma: Principles and Techniques,Semin. Interv. Radiol. 2010, 27, 14–28
• [11] Kehoe S., Tonkopi E., Abraham R., Boyd D., Predicting theThermal Responses and Radiopacity of Multicomponent Zinc–Silicate Bioglasses: A focus on ZnO, La2O3, SiO2 and TiO2, J.Non. Cryst. Sol. 2012, 358, 3388–3395
• [12] Kehoe S., Kilcup N., Boyd D., Evaluation of Cytotoxicity for NovelComposite Embolic Microspheres:Material Optimization by ResponseSurface Methodology, Mat. Lett. 2012, 86, 13–17[WoS]
• [13] Kehoe S., Abraham R., Tonkopi E., Boyd D., Novel RadiopaqueEmbolic Agent for Uterine Fibroid Embolization: Determinationof Radiopacity and Biological Evaluation; Cytocompatibility, IntracutaneousReactivity and Local Effects after Implantation, J.Vasc. Interv. Radiol. 2011, 23, S33[Crossref]
• [14] Kehoe S., Langman M., Werner-Zwanziger U., Abraham R.J.,Boyd D., Mixture Designs to assess Composition-Structure-Property Relationships in SiO2–CaO–ZnO–La2O3–TiO2–MgO–SrO–Na2O Glasses: PotentialMaterials for Embolization, J. Biomater.App. 2013, 28, 416–433[WoS]
• [15] Kehoe S., Tremblay M.T., Coughlan A., Towler M.R., Rainey J.K.,Abraham R.J., Boyd D., Preliminary Investigation of the DissolutionBehaviour, Cytocompatibility, Effects of Fibrinogen Conformationand Platelet Adhesion for Radiopaque Embolic Particles,J. Funct. Biomater. 2013, 4, 89–113[Crossref]
• [16] Kehoe S. Looney M., Kilcup N., Tonkopi E., Daly C., AbrahamR.J., Boyd D., Effects of 𝛾-Irradiation and Accelerated Aging onComposition-Structure–Property Relationships for RadiopaqueEmbolic Microspheres, J. Non. Crystal. Sol. 2014, 402, 84–90
• [17] Hasan M., Kehoe S., Boyd D., Temporal analysis of dissolutionby-products and genotoxic potential of spherical zinc–silicatebioglass: “Imageable beads” for transarterial embolization, J.Biomater. App. 2014, 29, 566–581
• [18] Pelage J.P., Polyvinyl Alcohol Particles versus Tris-acryl GelatinMicrospheres for Uterine Artery Embolization for Leiomyomas,J. Vasc. Interv. Radiol. 2004, 15, 789–791[Crossref]
• [19] Stampfl S., Stampfl U., Rehnitz C., Schnabel Ph., Satzl S.,Christoph P., et al., Experimental Evaluation of Early and Long-Term Effects of Microparticle Embolization in Two Different MinipigModels, Part I: Kidney, Cardiovasc. Interv. Radiol. 2007, 30,257–267[WoS][Crossref]
• [20] Araki N., Nagata Y., Fujiwara K., Aoki T., Mitsumori M., KimuraH., et al., Evaluation of Glass Microspheres for Intra-arterial Radiotherapyin Animal Kidneys, Int. J. Radiat. Oncol. Biol. Phys.2001, 49, 459–463[Crossref]
• [21] Stampfl S., Bellemann N., Stampfl U., Radeleff B., Lopez-Benitez R., Sommer C.M., et al., Inflammation and Recanalizationof Four Different Spherical Embolization Agents in thePorcine Kidney Model, J. Vasc. Interv. Radiol. 2008, 19, 577–586[WoS][Crossref]
• [22] Andrews R.T., Binkert C.A., Relative Rates of Blood Flow Reductionduring Transcatheter Arterial Embolization with Tris-acrylGelatin Microspheres or Polyvinyl Alcohol: Quantitative Comparisonin a Swine Model, J. Vasc. Interv. Radiol. 2003, 14, 1311–1316[Crossref]
• [23] Bilbao J.I., de Luis E., García de Jalón J.A., deMartino A., LozanoM.D., de la Cuesta A.M., et al., Comparative Study of Four DifferentSpherical Embolic Particles in an Animal Model: A Morphologicand Histologic Evaluation, J. Vasc. Interv. Radiol. 2008, 19,1625–1638[WoS][Crossref]
• [24] Stampfl S., Bellemann N., Stampfl U., Sommer C.M., ThierjungH., Lopez-Benitez R., Arterial Distribution Characteristics of EmbozeneParticles and Comparison with other Spherical EmbolicAgents in the Porcine Acute Embolization Model, J. Vasc. Interv.Radiol. 2009, 20, 1597–1607[Crossref][WoS]
• [25] Swindle M.M., Makin A., Herron A.J., Clubb Jr. F.J., Frazier K.S.,Swine as Models in Biomedical Research and Toxicology Testing,Veter. Pathol. 2012, 49, 344–356[WoS]
• [26] Siskin G.P., Englander M., Stainken B.F., Ahn J., Dowling K.,Dolen E.G., Embolic Agents used for Uterine Fibroid Embolization,2000, AJNR, 175, 767–773
• [27] Laurent A.,Wassef M.,Namur J.,Martal J., Labarre D., Pelage J.P.,2009, Recanalization and Particle Exclusion after Embolizationof Uterine Arteries in Sheep: A Long-Term Study, Fertil. Steril.2009, 91, 884–892[Crossref][WoS]
• [28] Arakawa H., Murayama Y., Davis C.R., Howard D.L., BaumgardneraW.L., Marks M.P., Do H.M., Endovascular Embolization ofthe Swine Rete Mirabile with Eudragit-E 100 Polymer, Amer. J.Neuroradiol. 2007, 28, 1191–1196[WoS][Crossref]
• [29] Germano I.M., Davis R.L., Wilson C.B., Hieshima G.B.,Histopathological Follow-up Study of 66 Cerebral ArteriovenousMalformations after Therapeutic Embolization withPolyvinyl Alcohol, J. Neurosurg. 1992, 76, 607–614[Crossref]
• [30] Davidson G.S., Terbrugge K.G., Histologic Long-Term Follow-upafter Embolizationwith Polyvinyl Alcohol Particles, Amer. J. Neuroradiol.1995, 16, 843–846
• [31] Schoen F.J., Levy R.J., Calcification of Tissue Heart Valve Substitutes:Progress toward Understanding and Prevention, Ann.Thorac. Surg. 2005, 79, 1072–1080 [Crossref]

Identyfikatory

DOI

10.1515/bglass-2015-0007