An efficiency of the nonsingular meshless method is analyzed in an acoustic indoor problem. The solution is assumed in the form of the series of radial bases functions. The Hardy’s multiquadratic functions, as the bases, are taken into account. The room acoustic field with uniform, impedance walls is considered. The representative, rectangular cross section of the room is chosen. Practical combinations of acoustic boundary conditions, expressed through absorption coefficient values, are considered. The classical formulation of the boundary problem is used. It is established any coefficient in the multiquadratic functions depend on the number of influence points, the frequency and the absorption coefficient. All approximate results are calculated in relation to the exact ones. This way, it is proved that the meshless method based on the multiquadratic functions is simple and efficient method in the description of the complicated acoustic boundary problems for the low and medium ranges of frequency.