The main object of the present paper is to investigate several results of certain differential operators which were recently introduced and (or) studied in a series of papers by Chen et et al. [1-3], Irmak et al. [8, 10, 11], Dziok et al. [5, 6] and Liu et al. . In addition, some applications of our results involving certain differential inequalities of multivalently analytic and (or) multivalently raeromorphic functions are given. Our certain results also include some recent results in [5, 6, 9, 11, 12].