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EN
A new simple, accurate, precise, rapid, and selective densitometric TLC method has been established for simultaneous analysis of aceclofenac, paracetamol, and chlorzoxazone in tablets. Identification and quantification were performed on 10 cm × 10 cm aluminium-backed TLC plates coated with 0.2 mm layers of silica gel 60 F 254 , previously washed with methanol, and using toluene-2-propanol-ammonia 4:4:0.4 (υ/υ) as mobile phase. Detection was performed at 274 nm. The R F values of aceclofenac, paracetamol, and chlorzoxazone were 0.28 š 0.01, 0.72 š 0.02, and 0.51 š 0.02, respectively. Calibration plots were linear in the range 400-1400 ng per band for aceclofenac, 2000-7000 ng per band for paracetamol, and 1000-3500 ng per band for chlorzoxazone, with correlation coefficients, r , 0.9995, 0.9993, and 0.9996, respectively. Recovery of aceclofenac, paracetamol, and chlorzoxazone were 99.54-100.44, 100.02-100.47, and 99.39-99.84%, respectively. The suitability of densitometric TLC for quantitative analysis of these compounds was proved by validation in accordance with the requirements of ICH Guidelines.
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