Calculation of the thermal dynamic properties of the multi-layer wall isolation of residential buildings is presented in this paper. Taking into account that the final objective is to create a building with the highest energy efficiency ratio, i.e. with the lowest energy consumption, both for heating and cooling, it is necessary to realize the good thermal characteristics of the multi-layer wall. To obtain the optimal solution for the wall's structure, various wall structures with different thicknesses of the individual layers, were analyzed. Based on results, presented in this paper, one can conclude that for walls with the same total thickness, but various thicknesses of the individual layers, that constitute the complete wall structure, the differences appear in the delay of the change of the walls outside temperature. In that way, by varying those individual layers' thicknesses, one can obtain the optimal solution for the wall structure with the highest savings of energy.