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Analysis of advanced technologies for 3D printing of pharmaceutical products for personalised medicine: A review

Panova N.K., Nikolova K.T., Dikova T.D.

Archives of Materials Science and Engineering

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2025

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Vol. 132, nr 1

29--41

EN

Purpose: of this paper is to make an analysis of the advanced technologies for 3D printing of pharmaceutical products for personalised medicine. Design/methodology/approach: A review of the basic 3D printing methods used in pharmaceutical technologies is conducted. The main types of printed solid dosage forms are examined, along with the primary advantages and disadvantages of 3D printing compared to conventional drug production. Each method is evaluated in terms of working principles, material compatibility, advantages, and limitations. Findings: Revealed that stereolithography (SLA), selective laser sintering (SLS), fused deposition modelling (FDM), ink-jet printing (IJP), and semi-solid extrusion (SSE) are the most suitable 3D printing processes for producing pharmaceutical products. The combination of two methods ensures better results, as illustrated by examples of the main types of printed solid dosage forms. Research limitations/implications: The 3D printing technologies for production of pharmaceutical products present several limitations such as: uneven geometries and porous structures, necessitating the fabrication of larger and irregular dosage forms to ensure the required drug load for the patient; degradation of thermolabile drugs during FDM process; increased hardness of FDM produced tablets impairing drug release. Practical implications: The advanced 3D printing technologies offer the ability to produce new formulations easily through simple design modifications in software, compared to conventional manufacturing. They enable the design of flexible formulations with complex release profiles and the personalised production of dosage forms tailored to individual patients. Originality/value: 3D printing has emerged as a transformative technology in pharmaceutical manufacturing, enabling the production of personalised dosage forms with precise drug loading, tailored release profiles, and complex geometries. The review not only summarises the main applicable techniques but also highlights the most recommended methods for personalised pharmacotherapy. The versatility and adaptability of 3D printing provide promising solutions for personalised therapy, emergency drug manufacturing, and enhanced patient compliance, marking a significant step toward decentralised, digital pharmaceutical production.

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Developing the competencies of medical students versus the challenges of coordinated and personalized medicine

Mendryk Iwona, Barłóg Katarzyna

Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska

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2024

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z. 197

25--39

EN

Purpose: The article discusses the specificity of coordinated and personalized medicine and the resulting demand for individual competences of medical graduates. Identification of the assumed knowledge, skills and professional attitudes of medical graduates is the main research goal. Design/methodology/approach: Qualitative research was conducted by analyzing existing data (desk research): the standards of medical education set by the Ministry of Science and Higher Education and the planned learning outcomes at five leading medical universities in Poland were analyzed. Findings: The analyzes carried out allowed us to determine the necessary competences are identified by health care specialists to perform medical professions. Education standards place little emphasis on the development of soft and organizational skills, which are necessary in the context of the development of coordinated and personalized medicine. Some universities independently expand learning outcomes with new technologies, protection of sensitive data, or analysis of large databases. The summary presents several key conclusions. Research limitations/implications: The results of the presented research were based on document analysis, which does not allow for generalizations in the conclusions. It would be important to conduct quantitative research among students and lecturers regarding the effects achieved during professional practice classes. Practical implications: The results of the analyzes lead to the conclusion that universities recognize the need to update the educational outcomes obtained during medical studies in terms of contemporary challenges, including aspects developing coordinated and personalized medicine. Conclusions may constitute recommendations regarding updating legal regulations of the Ministry of Higher Education. Social implications: Implementing changes to medical curricula would better prepare graduates for the challenges of modern medicine and the diagnosis, treatment and care of patients. Originality/value: The analyses carried out allowed the identification of the competences necessary for health care professionals to practice. The role of soft competencies in the delivery of health care services was indicated. In conclusion, some key conclusions were presented from the point of view of the assumptions of personalized medicine.

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Projekt utworzenia Polskiej Sieci Biobanków - aktualizacja postępu prac oraz zakres produktów oferowanych do wdrożenia w polskich biobankach ludzkiego materiału biologicznego

Kalinowski Leszek, Kozera Łukasz, Skokowski Jarosław

Laboratorium Medyczne

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2019

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nr 4

50--54

PL

Od niespełna trzech lat w Polsce funkcjonuje Konsorcjum BBMRI.pl jako narodowy reprezentant w europejskiej sieci biobanków Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-ERIC.eu), która jest organizacją naukową służącą realizacji badań wykorzystujących materiał biologiczny pochodzący od człowieka do rozwoju medycyny personalizowanej. Konsorcjum BBMRI.pl pracuje nad rozwiązaniami biotechnologicznymi i organizacyjnymi na rzecz utworzenia Polskiej Sieci Biobanków.

EN

The BBMRI.pl consortium has been functioning in Poland for less than three years as a national representative in the European biobanking network Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-ERIC.eu), which is a scientific organization serving the implementation of research using biological material from humans for the development of personalized medicine. The BBMRI.pl consortium is working on biotechnological and organizational solutions for the creation of the Polish Biobanking Network.

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Ethical consequences of current transformation processes of medicine from professional ethics point of view

Kovaľová D.

Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska

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2018

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z. 122

109--116

EN

In the paper, we emphasize the idea of radical changes in contemporary medicine that have occurred as a result of the unprecedented development of scientific and technological progress. There is a growing need to analyse the current state and problems in the field of medicine, to consider its new goals and perspectives with an emphasis on the ethical dimension. From a wide range of questions and problems of contemporary medicine, we examine the ethical aspects of the patient's autonomy, commercialization of medicine and personalized medicine. We point out that applied occupational ethics in this field also provides a strategy for cultivating professional responsibility for doctors (healthcare professionals).

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Narzędzie informacji geograficznej w aspekcie medycyny spersonalizowanej

Horodecka M.

Systemy Wspomagania w Inżynierii Produkcji

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2016

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z. 4 (16)

23--31

PL

Publikacja ta powstała na podstawie studiów literaturowych oraz źródeł wtórnych, charakteryzujących rolę medycyny spersonalizowanej w leczeniu pacjentów. Zwrócono w nim uwagę na potrzebę tworzenia profilu geograficznego pacjenta w medycynie spersonalizowanej, zwłaszcza w aspekcie migrujących społeczności. Przedstawiono także przykłady reakcji krajów wysokorozwiniętych na kształtowanie się medycyny spersonalizowanej i rekomendacje w Unii Europejskiej dot. medycyny spersonalizowanej oraz przytoczono postulat rozwoju medycyny w Województwie Śląskim. Ponadto zostały wskazane platformy komunikacji dotyczące zdrowia pacjenta.

EN

This article was prepared basing on the literature review and analysis of secondary sources, determining the role of customised medicine in treatment of patients. The attention was directed on the the need of creation of a geographical profile of the patient in customised medicine, particularly in the aspect of migrating societies. There were also presented some examples of reactions of higly developed countries on shaping of this type of medicine and appropriate recommendations in the European Union. There was also presented a postulate of development of customised medicine in the Silesia Region. There were also indcated platforms of communication regarding patient's health.