The purpose of this study was to develop a model for an integrated estimation of the functional state of the human organism (FSHO) and an integral estimation of physical factors (PF) for hygienic rating. Tests were performed twice with 3 men in 0.7-clo clothing during 4-hr mental work with 9 combinations of 4 PF: wideband noise (55–83 dB(A)), whole-body vibration (6 Hz, az =0.2–1.8 ms−2), air temperature (18–30 C), and illumination (1, 3, 5 lx). Thermoregulatory, cardiovascular, and psychophysiological reactions and temporary threshold of hearing (TTS2) shifts were studied. For the integral estimation of PF influence on FSHO the model F(y1, y2, ... ym) = f(x1, x2, ... xn) was used, relating both FSHO and PF sets. The most important physiological parameters in creating FSHO are defined and the contribution of individual parameters of FSHO and PF is found.