Today, in-process force measurement is required by many manufacturing applications, such as process monitoring, quality assurance, or adaptive process control. A very promising force measurement approach bases on sensor-integration into the machine structure and is particularly suitable for hexapod structures and kinematics, where it allows a measurement in 6 degrees of freedom. On the other hand, a sensor integration also affects the machine. Especially for strain-gauge-based force sensors, a stiffness reduction is predicted, as their measuring principle requires a deformation. The practical consequences of these influences are investigated in this contribution. In particular, this work presents extensive experimental studies of the stiffness change caused by sensor integration for a single hexapod strut as well as for the complete hexapod machine tool. The results are evaluated in comparison to compliances of other components, such as the kinematic joints, and to stiffness changes resulting from sensor-integration into the end-effector or the application of a commercial force/torque sensor at the end-effector. In conclusion, the studies support the approach of structure-integrated force measurement for parallel kinematics, as the stiffness loss is rather small in many cases.