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EN
The article presents the results of a theoretical study, the purpose of which was to analyze the basic principles of development of volitional qualities of student youth as a holistic systemic individual psychological characteristics in the process of physical culture and sports. Scientific novelty lies in the theoretical substantiation of volitional qualities of students in the process of physical culture and sports, it is in the process of physical education clearly defines the goals and content of activities, tools and methods that affect the development of determination, perseverance, endurance, determination, courage, ie. form a habit of showing the willful efforts of young people. The concept of „will” from the point of view of philosophers, psychologists and teachers is described. The modern definition of will is consistent with the fact that it is a conscious self-regulation of human activities, which provides overcoming obstacles and difficulties on the way to his goal. It is noted that in the process of physical education a necessary condition for the formation of the child’s will is to master the techniques, increase the level of physical fitness. At the same time, psychological and pedagogical methods of stimulation should be taken into account: praise, awards and other techniques that increase students’ interest in classes and contribute to a significant increase in selfconfidence. The volitional efforts in the process of physical culture and sports activities are analyzed and five of their types are distinguished: volitional efforts at muscular tensions; volitional efforts under stress; volitional efforts when performing actions to overcome fatigue; strong-willed efforts aimed at adhering to the regime; volitional efforts are aimed at overcoming feelings of fear.
PL
W artykule przedstawiono wyniki teoretycznego badania, którego celem była analiza głównych zasad rozwoju siły woli uczniów, jako całościowych, systemowych cech indywidualno-psychologicznych, w procesie wychowania fizycznego i sportu. Nowatorstwo naukowe polega na badaniu teoretycznego ugruntowania siły woli uczniów w procesie wychowania fizycznego i sportu. To właśnie w procesie wychowania fizycznego, cele i treści działań, środki i metody, wpływają na realizację celów kształcenia wytrwałości, wytrzymałości. Determinacja, odwaga są jasno określone, tj. tworzą nawyk okazywania młodym ludziom silnej woli. Pojęcie „woli” jest scharakteryzowane z punktu widzenia filozofów, psychologów i nauczycieli. Współczesna definicja woli jest zgodna z faktem, że jest to świadoma samoregulacja przez osobę swoich działań, zapewniająca pokonywanie przeszkód i trudności na drodze do celu. Zwraca się uwagę, że w procesie wychowania fizycznego warunkiem koniecznym kształtowania się woli dziecka jest opanowanie różnych technik, służących podnoszeniu poziomu sprawności fizycznej. Jednocześnie należy wziąć pod uwagę psychologiczne i pedagogiczne metody stymulacji: pochwały, nagrody i inne metody, które zwiększają zainteresowanie uczniów zajęciami, przyczyniając się do znacznego wzrostu pewności siebie. Przeanalizowano wysiłki wolicjonalne w procesie kultury fizycznej i aktywności sportowej, wyróżniając pięć ich typów: wysiłek wolicjonalny podczas napięcia mięśniowego; wolicjonalne wysiłki podczas zwracania uwagi; wolicjonalne wysiłki podczas wykonywania działań, mających na celu przezwyciężenie zmęczenia; dobrowolne wysiłki, ktore mają na celu utrzymanie reżimu; wysiłki wolicjonalne służące przezwyciężeniu uczucia strachu.
2
Content available remote Woltamperometryczne oznaczanie tymolu w preparatach farmaceutycznych
PL
Opracowano prostą, szybką i czułą metodę woltamperometrycznego oznaczania tymolu w farmaceutykach. Podstawą badań jest proces jego utleniania na mikroelektrodzie platynowej w lodowatym kwasie octowym zawierającym acetonitryl (20% obj.) oraz 0,1 mol/L chloranu(VII) sodu jako elektrolit podstawowy. Uzyskano liniową odpowiedź sygnału woltamperometrycznego (DPV) w szerokim zakresie stężeń 0,5-1105 mg/L, przy niskiej wartości granicy wykrywalności wynoszącej 0,05 mg/L. Analizę ilościową przeprowadzono metodą wielokrotnego dodatku wzorca.
EN
Content of thymol in pharmaceutical preparations was detd. by differential pulse voltammetry at a Pt microelectrode (25 μm diam.) in a mixt. of glacial AcOH and MeCN (8:2 by vol.) with 0.1 M NaClO₄. A good accuracy and precision of the DPV method was achieved and its usefulness in routine anal. was confirmed.
EN
A rapid and simple UPLC-MS/MS method was developed to determine toddalolactone in mouse blood and applied to measure the pharmacokinetics of toddalolactone in mice. Blood samples were first preprocessed by ethyl acetate liquid-liquid extraction. Oxypeucedanin hydrate (internal standard, IS) and toddalolactone were gradient eluted from a UPLC BEH C18 column using a mobile phase consisting of acetonitrile and water (0.1% formic acid). Using electrospray ionization (ESI) as the ionization source, multiple reaction monitoring was used to detect the precursor and product ions of m/z 309.2 and 205.2, respectively, for toddalolactone and of m/z 305.1 and 203.0 for IS, respectively, for quantitative detection. A calibration curve was run over the concentration range of 5–4,000 ng/mL (r > 0.995). The matrix effects ranged from 93.5 to 98.4%, and the recovery was higher than 77.3%. The precision was less than 13%, and the accuracy ranged from 90.9 to 108.4%. The developed UPLC-MS/MS method was successfully used for measuring the pharmacokinetics of toddalolactone in mice after oral (20 mg/kg) and intravenous administration (5 mg/kg), and the absolute bioavailability of toddalolactone was 22.4%.
EN
Narciclasine is a 7-hydroxy derivative of lycorisidine. It was the first alkaloid isolated from the stem of narcissus (Amaryllidaceae) in 1967. Six mice were given narciclasine (5 mg/kg) by intravenous administration. A UPLC-MS/MS method was developed to determine narciclasine in mouse blood. Tectorigenin (internal standard, IS) and narciclasine were gradient eluted by mobile phase of methanol and 0.1% formic acid in a BEH C18 column. The multiple reaction monitoring (MRM) of m/z 308.1→248.1 for narciclasine and m/z 301.1→286.0 for IS with an electrospray ionization (ESI) source was used for quantitative determination. The calibration curve ranged from 1 to 6,000 ng/mL. The accuracy was from 92.5 to 107.3%, and the matrix effect was between 103.6 and 107.4%. The developed UPLC-MS/MS method was successfully applicated to a pharmacokinetic study of narciclasine in mice after intravenous administration (5 mg/kg).
EN
Eugenitin is a non-volatile chromone derivative which is always found in dried flower buds of Syzygium aromaticum L. (Merr.) & L.M. Perry. Until now, there were no reports about the pharmacokinetics of eugenitin in biological fluids. A UPLC-MS/MS method developed to determine eugenitin in mouse blood. The blood samples were prepared by protein precipitation with acetonitrile. Chrysin (internal standard, IS) and eugenitin were gradient eluted by mobile phase of acetonitrile and water (0.1% formic acid) in a BEH C18 column. The multiple reaction monitoring (MRM) of m/z 221.1→206.0 for eugenitin and m/z 255.1→152.9 for IS with an electrospray ionization (ESI) source was used for quantitative detection. The calibration curve ranged from 0.5 to 500 ng/mL (r > 0.995). The accuracy ranged from 98 to 113%, the precision was less than 12%, and the matrix effect was between 86 and 94%, the recovery was better than 81%. The developed method was successfully used for pharmacokinetics of eugenitin in mice after intravenous (5 mg/kg) and oral (20 mg/kg) administration, and the absolute availability of eugenitin was 12%.
6
EN
The variety of the chemical forms of phosphorus compounds occurring in plant tissues, accompanied by the complexity of the chemical composition of plants as the analytical matrices, are the reasons why there is no one, the best answer, how those individual substances may be determined qualitatively and quantitatively. Interestingly, if the subject of determination is the total phosphorus content, the spectrum of effective methods and techniques seems to be impressive. However, in case of spectrophotometric measurements and classical variants of absorption (FAAS) or emission (ICP-AES/ ICP-OES) spectrometry techniques, it is necessary at first to isolate various phosphorus forms from the matrix, and then to mineralize them prior determination. The development of combined methods e.g. ETV-ICP- AES or HR-ETAAS, does allow the isolation of the phosphorus analyte and its detection in a kind of “one step” analytical procedure, directly in plant tissues. Similar benefits, while maintaining the sensitivity of determinations, are brought by the use of XRF, SIMS or nanoSIMS - more expensive techniques of imaging the presence of phosphorus in biological matrices. In turn, the application of nuclear magnetic resonance spectroscopy, especially the 31P NMR technique is thought to be the most universal approach. Using this technique and being aware of higher limit of detection, it is possible to determine various plant phosphorus compounds qualitatively and quantitatively, at the same time.
PL
W trzeciej części cyklu artykułów dotyczących zginanych ścian murowanych, obciążonych prostopadle do ich powierzchni [5, 6] omówiono sposoby analizy tego rodzaju konstrukcji, w tym założenia dotyczące warunków brzegowych modeli ścian jednowarstwowych i szczelinowych. Przedstawiony został również sposób określania wartości momentów zginających przyjęty w normie PN-EN 1996-1-1.
EN
In the third part of the series of articles on bent masonry walls, loaded perpendicular to their surfaces [5, 6], methods of analysis of this type of structure are discussed, including assumptions regarding the boundary conditions of single-leaf and cavity wall models. The method of determining the values of bending moments adopted in the PN-EN 1996-1-1 standard is also presented.
PL
Przedstawiono algorytm oznaczania grubości warstw nawierzchni drogowych metodą georadarową, zapewniający uzyskanie możliwie największej dokładności przy minimalizacji liczby odwiertów koniecznych do wykonania. Zastosowanie algorytmu umożliwia zredukowanie błędów oznaczeń grubości bez wykonywania odwiertów z ±30 do ±10% rzeczywistej grubości, tj. do mieszczących się w zakresie tolerancji pomiarowej metody georadarowej.
EN
The article presents an algorithm for determining the thickness of road pavement layers using GPR method which allows to obtain the highest possible accuracy while minimizing the number of drillings required. Presented algorithm allows to reduce errors in road pavement layers thickness determination using the GPR method without drilling from ± 30% to ± 10% of the actual thickness, i.e. to the GPR method tolerance range.
EN
The subject of the wind tunnel tests is a steel chimney 85 m high of cylindrical - type structure with a grid-type curtain structure situated at its upper part. The model of the upper part of the chimney made in the scale of 1:19 was equipped with 3 levels of wind pressure measurement points. Each level contained 24 points connected with pressure scanners. On the base of the pressure measurements, both mean and instantaneous aerodynamic drag and side force coefficients were determined. Next wind gust factors for these two wind action components were determined. Moreover, for each pressure signal Fast Fourier Transform was done. Mean wind action components were also determined using stain gauge aerodynamic balance. Obtained results make possible to conclude that the solution applied in the upper part of the designed chimney is correct from building aerodynamics point of view. Some minor vortex excitations were observed during model tests of the upper part of the chimney. The basic dynamic excitation of this part of the chimney is atmospheric turbulence.
PL
Przedmiotem badań w tunelu aerodynamicznym był stalowy komin wysokości 85 m, o konstrukcji cylindrycznej z umieszczoną w górnej części konstrukcją siatki osłonowej. Model górnej części komina wykonany w skali 1:19 został wyposażony w 3 poziomy punktów pomiarowych ciśnienia wiatru. Każdy poziom zawierał 24 punkty połączone ze skanerami ciśnienia. Na podstawie pomiarów ciśnienia wyznaczono średni i chwilowy współczynnik oporu aerodynamicznego oraz współczynniki siły bocznej. Następnie określono współczynniki porywów wiatru dla tych dwóch składowych działania wiatru. Ponadto dla każdego sygnału ciśnienia wykonano szybką transformację Fouriera. Średnie składowe siły działania wiatru zostały również określone przy użyciu wagi aerodynamicznej. Uzyskane wyniki pozwalają stwierdzić, że rozwiązanie zastosowane w górnej części projektowanego komina jest poprawne z punktu widzenia aerodynamiki budowli. Podczas badań modelowych górnej części komina praktycznie nie zaobserwowano wzbudzeń wirowych. Podstawowym wzbudzeniem dynamicznym tej części komina są turbulencje atmosferyczne.
10
Content available remote Pharmacokinetics and bioavailability of liensinine in mouse blood by UPLC-MS/MS
EN
Liensinine is a bisbenzyltetrahydroisoquinoline alkaloid extracted from lotus (Nelumbo nucifera GAERTNER., Nelumbonaceae), especially in its embryo loti “Lien Tze Hsin” (green embryo of mature seed). A rapid and simple UPLC-MS/MS method was developed to determine liensinine in mouse blood and its application to a pharmacokinetic study. The blood samples were preprocessed by protein precipitation using acetonitrile. Midazolam (internal standard, IS) and liensinine were gradient eluted by mobile phase of methanol and water (0.1% formic acid) in a Waters UPLC BEH C18 column. The multiple reaction monitoring of m/z 611.3 → 206.1 for liensinine and m/z 326.2 → 291.1 for IS with an electrospray ionization (ESI) source was used for quantitative detection. The calibration curve ranged from 0.5 to 400 ng/mL (r > 0.995). The accuracy ranged from 92.2 to 108.2%, the precision of intra-day and inter-day was less than 14%, and the matrix effect was between 100.0% and 109.6%, the recovery was better than 71.0%. The developed UPLC-MS/MS method was successfully used for a pharmacokinetic study of liensinine in mice after oral (5 mg/kg) and intravenous administration (1 mg/kg), and the absolute availability of liensinine was 1.8%.
EN
This study focused on developing an effective and environmentally friendly method to measure ligustrazine in rat serum by using polymer monolith micro-extraction (PMME) technique. A poly (methacrylic acid-ethylene glycol dimethacrylate) material was used to extract ligustrazine through hydrophobic and ion-exchange interaction. Qualitative and quantitative analysis was performed by a liquid chromatography and tandem mass spectrometry. After optimization of several PMME conditions, the developed method exhibited excellent extraction performance to the ligustrazine. Good linearity was acquired ranging from 10 to 2,000 ng mL−1, and the limit of detection of the proposed method was 0.14 ng mL−1. The recoveries measured by spiking three different concentrations in rat serum ranged from 82.6 to 95.3%, and excellent precision was found with relative standard deviations (RSDs) less than 8.3% for intra-day and 9.7% for inter-day, respectively. At last, the applicability of the method was further confirmed through continuous monitoring of ligustrazine in rat serum after dosing of ligustrazine tablets to rats.
EN
The analyzed organosilicon derivatives of electrostatically stabilized silanates belong to a group of pentacoordinated compounds. These derivatives are:1-(N-morpholiniomethyl)spirobi(1-sila-2,5-dioxacyclopentan-3-on)at,1-(N-morpholiniomethyl)spirobi(1-sila-2,5-dioxa-4-methylcyclopentan-3-on)at,1-(N-morpholiniomethyl)spirobi(1-sila-2,5-dioxa-4-(i-propyl)cyclopentan-3-on)at. In the course of the work, the extraction process and optimization of conditions for separation and determination of a mixture of electrostatically stabilized silanates were carried out using capillary isotachophoresis. Proper leading electrolytes were elaborated developed and the terminating electrolyte:4,4’-bis[(1-morpholiniomethyl)spirobi(1-sila-2,5-dioxacyclopentan-3-on)at] was proposed. The extraction process involved the use of three stationary phases: octadecyl, octyl and phenylpropyl. The highest recovery values, approx. 94%, were obtained on the phenylpropyl column. The optimum time of analysis by the isotachophoretic technique did not exceed 12 min. The developed method of separation and determination of electrostatically stabilized silanates expands the possibility of research on biological activity of this group of compounds in aqueous solutions and surface water vegetation.
PL
Zastosowanie technologii MALDI i technik elektromigracyjnych w analizie mikrobiologicznej może stać się kamieniem milowym w diagnostyce i analizie zakażeń.
EN
Due to the development of alternative propulsion systems, there is a need for LNG tanker turbine propulsion plants to regain their competitiveness. Previous research revealed effective methods to increase the thermal efficiency of the steam cycle based on quality assessment, and it was proposed that the latent heat of the main turbine exhaust steam could be recovered. Research was carried out for the steam cycle using regenerative heat exchangers fed by steam jet injectors. In this paper, an algorithm to determine the operating parameters of steam jet injectors, and the calculation results for different drive steam parameters are presented. The obtained results will be used as input parameters for further heat balance calculations of the proposed regenerative steam cycles.
EN
The article presents a simulation method for determining the minimum safe pull of tugs assisting in port manoeuvres. The method can be used to determine the relationship between the minimum safe pull, understood as the tension on the line, of the assisting tugs and the overall length, cargo capacity or net capacity of ships manoeuvring in a given port under allowable hydrometeorological conditions. The method was verified through simulated tests of gas tankers’ entry, turning and berthing at the LNG terminal of Świnoujście.
EN
A new method for determination of positive realizations of given transfer matrices of linear continuous-time linear systems is proposed. Necessary and sufficient conditions for the existence of positive realizations of transfer matrices are presented. A procedure for computation of the positive realizations is proposed and illustrated by an example.
EN
A new method for computation of positive realizations of given transfer matrices of fractional linear continuous-time linear systems is proposed. Necessary and sufficient conditions for the existence of positive realizations of transfer matrices are given. A procedure for computation of the positive realizations is proposed and illustrated by examples.
EN
In order to reduce the number and time of layups and to increase the period of effective operation of a mechatronic system it is reasonable to carry out predictive recovery works during one stoppage (repair) for a group of component parts with equal, close or multiple operation hours to the prior-to-failure (limiting) state. Such approach gives also the possibility to carry out recovery works with separate elements in parallel, which allows to reduce the system layup time and to increase the production output.
EN
Attention has been paid to healthy lifestyle in recent years. This is possible through increased physical activity and proper nutrition. This involves a significant increase in the interest in natural ingredients in a human daily diet. They come from both vegetable and animal products. This group of substances includes, for example, ascorbic acid (vitamin C), tocopherol (vitamin E), vitamin D, coenzyme Q10 and others. The important role of many compounds provided with food is their antioxidant action, which protects the body against the harmful effects of reactive oxygen species. They also exhibit therapeutic effects in diseases caused by oxidative stress. α-Lipoic acid (LA) also fits well into this group of substances and even gains the title of an “universal antioxidant” and an “antioxidant of antioxidants”. LA is produced in the human body in small amounts, and its biosynthesis occurs in the mitochondria. It is a compound with a very broad spectrum of therapeutic and biological activity. The amounts produced in the body are not sufficient and should therefore be supplied to the body from external sources. Food is the second, except de novo synthesis, the source of this compound. LA is a great antioxidant that can counteract the effects of aging. It is used mainly in the treatment of diabetic neuropathy and cardiovascular diseases, multiple sclerosis and Alzheimer’s disease. Such a wide action and occurrence causes the development of determination methods. Literature data indicate that free LA is primarily determined by liquid and gas chromatography, capillary electrophoresis, spectrophotometric and electrochemical techniques. In plant and animal cells it is mainly in the form of lipoyllysine. Determination of such a bound LA requires the proper preparation of the sample. This is usually acid, alkaline or enzymatic hydrolysis. This review summarizes the basic physicochemical and biochemical properties of α-lipoic acid and the methods of its determination.
PL
Przedstawiono analizę porównawczą wyznaczania fal nadciśnienia procedur własnych z wynikami badań doświadczalnych oraz teoretycznymi innych autorów i procedur. Analizę parametrów wybuchu zewnętrznego przeprowadzono, uwzględniwszy różne masy ładunków i ich odległości od ściany oraz porównano z wynikami doświadczalnymi. Ciśnienie wybuchu wewnętrznego porównano z wynikami przy stałej masie ładunku, ale w przypadku różnych punktów pomiarowych. Podano sposób uwzględnienia zmiennych kątów padania fali nadciśnienia.
EN
The paper presents the comparative analysis of the determination of overpressure waves procedures authors with the experimental and the theoretical other authors and procedures results. We presented the general characteristics of the internal and external impact of the explosion. Analysis has been performed for the external explosion for different mass loads and their distance from the wall, and compared with the experimental results. While the pressure of an internal explosion is compared to a constant weight load, but different measuring points. In the paper included how to take into account the variable angles of arrival overpressure wave.
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