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1

Investigating optimal conditions for obtaining medicinal extracts with the best functional properties from Kleinia anteuphorbium L.

Naama Amal, Aghoutane Basma, EL-Otmani Najlae, EL Monfalouti Hanae, Kartah Badr Eddine

Ecological Engineering & Environmental Technology

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2025

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Vol. 26, iss. 3

171--182

EN

Kleinia anteuphorbium L. is a medicinal plant widely utilized in traditional medicine by the Souss-Massa population. This study aimed to investigate the best extraction conditions, including method and solvents, to achieve the highest polyphenol, flavonoid, antioxidant, and antibacterial activities. The polyphenol and flavonoid contents were quantified using spectrophotometric methods, while the antioxidant activity was assessed through Ferric Reducing Power (FRAP) and 2,2-diphenyl-picrylhydrazyl radical (DPPH) scavenging assays. The antibacterial activity was assessed against four pathogenic clinical isolates: P. aeruginosa, E. coli, K. pneumonia, and S. aureus. The phytochemical analysis revealed that all extracts of Kleinia anteuphorbium exhibited high polyphenol and flavonoid contents, along with significant antioxidant activity. Moreover, the extracts showed inhibitory effects against the tested bacteria strains. The GC-MS analysis revealed the existence of abundant bioactive compounds, with potential therapeutic activities. These findings suggest that Kleinia anteuphorbium has promising potential as a medicinal plant.

2

Study the effect of zinc oxide nanoparticles on degradation, antibacterial, thermal and morphological properties of polyvinyl alcohol films

Sabr Ohood Hmaizah, Obaid Massar Najim, Al-Mutairi Nabeel Hasan, Krynke Marek, Mielczarek Krzysztof

Production Engineering Archives

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2024

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Vol. 30, Iss. 4

528--536

EN

In this study, a film was prepared from polyvinyl alcohol (PVA) and zinc oxide (ZnO) nanoparticles (nano-ZnO) via the casting method. Nanoparticles were added to PVA biopolymer to create reinforced biocomposite films with different loading contents (2, 4, and 6 wt.%), and they were tested by performing the following assays: the FTIR test, the antibacterial, soil burial test, DSC, AFM, and SEM. The results showed an improvement of the membranes in the antibacterial properties for both Escherichia coli (E. coli, Gram-negative) and Staphylococcus aureus (S. aureus, Gram-positive) when nano-ZnO was added. The biodegradation through weight loss was observed for all samples, and the results showed that the weight loss increased with the increase in ZnO nanoparticle content from 2% to 6% wt. The DSC results showed that the addition of ZnO led to an increase in Tg, and increasing the degree of glass transition led to an increase in the degradation rate. In the FTIR results, only physical interference was observed; no chemical interference was evident. The AFM results showed some agglomerations of nano-ZnO in the PVA matrix led to an increase in the surface roughness of the PVA/nano-ZnO film.

3

Copper oxide–ferric oxide nanocomposite: Synthesis, characterization, and antibacterial and antifungal properties

Elnouby Mohamed, Nabil Marwa, Al-Askar Abdulaziz A., Kowalczewski Przemysław, Abdelkhalek Ahmed

Materials Science Poland

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2024

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Vol. 42, No. 3

100--110

EN

Recently, copper oxide–ferric oxide nanocomposites (CuO/Fe2O3-NCs) have gained popularity and are widely employed in various applications. However, their effectiveness against phytopathogens has not been studied yet. This study investigates the synthesis and characterization of CuO/Fe2O3-NCs using the hydrothermal technique. X-ray diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and Fourier-transform infrared spectroscopy (FTIR) were used to characterize the produced nanocomposite (NC). EDX and TEM analyses revealed the presence of Cu, Fe, and O elements. The NC had a polygonal shape with sides around 12 nm, spherical CuO particles of 7–10 nm, and plate-likeFe2O3. XRD measurements confirmed the crystal and hexagonal structures of CuO and Fe2O3. The XRD patterns of CuO/Fe2O3 showed the characteristic peaks of (−111) and (004) reflections for CuO at 35.69° and 37.73°. The FTIR spectra showed characteristic lines at 525 and 567 cm−1 for the Cu–O bond and Fe–O stretching modes of Fe2O3, respectively. The antifungal activity of CuO/Fe2O3-NCs showed significant growth inhibition of Fusarium oxysporum, Rhizoctonia solani, and Botrytis cinerea by up to 71, 50, and 81%, respectively, at 100 µg/mL. At 50 µg/mL, the antibacterial test revealed inhibition zones of 12.33 mm for Pectobacterium carotovorum, 9.33 mm for Streptomyces scabies, 10.67 mm for Pectobacterium atrosepticum, and 14.67 mm for Ralstonia solanacearum. The results show that CuO/Fe2O3-NCs can efficiently suppress the growth of various fungal and bacterial strains, making them potential antimicrobial agents against phytopathogenic microorganisms.

4

Synergistic Effect of Silk Fibroin/Chlorogenic Acid/Citric Acid on Anti-ultraviolet and Antibacterial Properties of Cotton Fabric

Xiao Minghui, Zhang Wei

Fibres & Textiles in Eastern Europe

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2024

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Vol. 32, no. 1

76--82

EN

In order to obtain a durable anti-ultraviolet and antibacterial cotton fabric, silk fibroin, honeysuckle extract (chlorogenic acid) and citric acid were used to prepare a compound environment-friendly finishing agent, and then the cotton fabric was modified in this paper. Micro-morphology and properties were compared between cotton fabrics finished with a composite solution of silk fibroin/chlorogenic acid/citric acid and those finished first with silk fibroin then chlorogenic acid. Results showed that amidation and esterification crosslinking reactions occurred between the compounds and cotton fibers. Cotton fabric treated with the composite solution had higher UPF value (>90 after 30 launderings) and antibacterial rates (>95% for Staphylococcus aureus and Escherichia coli). There existed strong covalent bonds and good synergistic effects among silk fibroin, citric acid and chlorogenic acid, which could endow the cotton fabric with more durable anti-ultraviolet and antibacterial properties.

5

Dyeing and Performance Testing of Chitosan-Modified Cotton Fabrics with Tea Polyphenols

Zhao Lixue, Zhu Chunyan, Lin Yanping, Yang Chen

Fibres & Textiles in Eastern Europe

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2024

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Vol. 32, no. 4

22--30

EN

Tea polyphenols are one of the primary components of tea leaves and possess various beneficial effects, including radiation resistance, detoxification, antioxidation, antibacterial properties, anti-aging effects, digestive support, anti-cancer properties, and immune system enhancement. This study focuses on utilizing tea polyphenols for the functional finishing of chitosan-modified cotton fabrics, with the aim of developing an environmentally friendly and efficient green functional finishing process. The analysis reveals that the optimal dyeing parameters for cotton fabrics modified with chitosan and using a mass fraction concentration of 3% tea polyphenols are as follows: a pH value of 7, temperature of 50°C, dyeing time of 60 minutes, and a tea polyphenol o.w.f concentration exceeding 6%. Under these processing conditions, the chitosan-modified cotton fabrics demonstrate excellent colorfastness to sunlight, water, and friction, all exceeding grade 4. Furthermore, they exhibit good antibacterial properties, UV protection, and odor resistance, making them highly practical.

6

Comparative Analysis of Phenolic and Flavonoid content, Antioxidant, Antibacterial Activities, and Functional Groups of Chemicals from Hypericum perforatum L., and Papaver Rhoeas L. Flower Extracts

Afqir Hajar, Belmalha Saadia, Farihi Ayoub, Elbouzidi Amine, Bouhrim Mohamed, Elrherabi Amal, Boutagayout Abdellatif, Oubihi Asmae, Ouhssine Mohammed

Ecological Engineering & Environmental Technology

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2024

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Vol. 25, iss. 2

88--101

EN

In this study, the authors aimed to compare the phytochemical compounds (polyphenols and flavonoids), antioxidant activity, functional groups present in the compounds (FTIR), and anti-microbial effects, in the aqueous and methanol extracts obtained from flowers of commercial Hypericum perforatum and native Papaver Rhoeas from Morocco. P. Rhoeas L was collected from El Lhaj Kaddour near Meknes, while H. perforatum L was bought in a dried state from a Moroccan herbalist in the same city. Total polyphenols were evaluated using the Folin-Ciocalteu reagent, respectively. The antioxidant activity was assessed via DPPH and antimicrobial effects were tested against six bacteria (Gram– and Gram+). The aqueous and methanol extracts of P. Rhoeas had the highest TPC value (23.67 ± 0.94 mg GAE/g; 15.86 ± 0.65 mg GAE/g) compared to H. perforatum (15.26 ± 1.30 mg GAE/g; 5.50 ± 1.13 GAE/g). The aqueous extract of Papaver Rhoeas exhibited the highest TFC at 14.36 ± 0.49 mg QE/g, while the methanol extract of Hypericum perforatum had the highest 10.65 ± 0.49 mg QE/g in TFC. In contrast, the methanol and aqueous extracts of H. perforatum showed significant zones of inhibition against Staphylococcus aureus (9.5 ± 0.5 mm and 10.17 ± 0.29 mm) and Staphylococcus epidermidis (8.33 ± 0.58 mm and 9.33 ± 0.58 mm) respectively, with a minimum inhibitory concentration was estimated at 10 μL/ml. The FTIR analysis demonstrated that the extracts of both plants are rich in bioactive molecules with potential biological activities and a pharmaceutical industry perspective. Consequently, these Papaver Rhoeas and Hypericum perforatum extracts exhibit antioxidant and antibacterial activities.

7

Assessment of Phytochemical, Antioxidant and Antibacterial Properties of Ziziphus lotus Fruit Extracts

El Yakoubi Nosair, El Ahmed Annaoui, Rehhali Mohammed, Ansari Zineb Nejjar, Bounab Loubna, El Kbiach Mohammed L’bachir, El Bouzdoudi Brahim

Ecological Engineering & Environmental Technology

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2024

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Vol. 25, iss. 11

377--388

EN

One of the main sources of novel chemicals with possible medical use is medicinal plants. Multiple diseases have been treated with them in traditional medicine. The purpose of this study was to explore the phytochemical characteristics, antioxidant effects, and antibacterial activities of several extracts of Ziziphus lotus fruits (ZLF). Phytochemical analysis of ZLF extracts revealed the presence of several bioactive molecules such as phenolic compounds and alkaloids. Water, methanol 50%, methanol 80%, methanol, ethanol, and hexane are the 6 different solvents which were used in order to evaluate the phytochemical profile as well as the biological activities of ZLF, and whose aqueous extract showed the best results. The aqueous extract had the highest yield, followed by methanol, ethanol, and lastly hexane (p < 0.05). The aqueous extract showed the highest total contents of phenols, flavonoids, and tannins (77.13 ± 0.11 mg GAE /g DM, 33.36 ± 0.51 mg QE/g DM, and 03.72 ± 0.16 mg CE/g DM respectively), while the Hexane extract revealed the lowest contents (12.36 ± 0.26 mg GAE/g DM, 06.20 ± 0.23 mg QE/g DM, and 01.20 ± 0.10 mg CE/g DM respectively). By using the DPPH, ABTS, and FRAP methods, and for the aqueous extract, ZLF extracts demonstrated considerable antioxidant capacities, with the values IC50 = 37 ± 0.27, IC50 = 67 ± 0.18 and IC0.5 = 31 ± 0.22 respectively. All of the ZLF extracts, with the exception of the hexanic extract on Staphylococcus aureus, showed antibacterial efficacy against the bacterial strains of Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The results obtained reveal that ZLF exhibit significant biochemical composition and considerable biological activities encouraging its nutritional and therapeutic use.

8

HPLC-DAD method validation for quantiﬁcation of dehydroabietic acid and abietic acid in oral spray containing Pinus merkusii heartwood extract and its antibacterial effects on clinically isolated Streptococcus mutant

Sakunpak Apirak, Saingam Worawan

Acta Chromatographica

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2024

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Vol. 36, no. 3

228--236

EN

Pinus merkusii Jungh & De Vries. has become increasingly gathered more attention from researchers because the plant has a range of folk medicinal uses. Heartwood plant is the major source of dehydroabietic acid (DHAA) and abietic acid (AA), which possesses several medicinal properties, such as antiviral, antimicrobial, antiobesity and anti-inﬂammatory. The research proposed herein a low-cost, fast, speciﬁc, uncomplicated, sensitive, precise reverse-phase high-performance liquid chromatography (RP-HPLC). This method was conducted and validated for evaluating an amount of DHAA and AA in ethanol extract and oral spray containing P. merkusii heartwood extract. Additionally, stability and antimicrobial activities against clinically isolated Streptococcus mutans of the oral spray were determined. The separation was achieved on Pursuit 200Å PFP column, 150 3 4.6 mm, particles of 3 μm with a ﬂow rate of 1.0 mL min-1. Methanol and water (70:30 v/v) were used as eluent with an isocratic mode and sample analysis volume was set at 10 μL, at a detection wavelength of 210 and 245 nm. The developed HPLC method for analysis of DHAA and AA showed good linearity with correlation coefﬁcients equal to 1. Moreover, other validation parameters, comprised of accuracy, precision, speciﬁcity and detection and quantitation limits of this method displayed excellent reliability, validity and sensitivity. This method could be an interesting alternative for quantitative measurement of P. merkusii heartwood extract, oral spray formulation and other P. merkusii heartwood extract preparations. The result from antibacterial tests suggested that the oral spray containing P. merkusii heartwood extract is able to inhibit the oral pathogens causing dental caries. The oral spray decreased S. mutans population size by about 0.5–2 Log CFU mL-1 at 1–4 h and complete elimination of all bacteria strains within 24 h. This study provides validity for using P. merkusii heartwood extract as an alternative for preventing and treating oral infectious diseases.

9

Utilization of Tar Waste from the Gasification Process of Landfill Waste as a Disinfectant

Pramadaningtyas Putri Segi, Rachmawati Siti, Setyono Prabang, Himawan Widhi

Journal of Ecological Engineering

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2023

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Vol. 24, nr 10

315--323

EN

Gasification is a combustion process that can converts waste into electricity. Tar waste is liquid waste from the gasification process that has not been managed and utilized. Tar waste contains toxic compounds that can pollute the environment if they enter it. Tar waste has the potential to be used as a raw material for disinfectants because it contains phenol and polycyclic aromatic hydrocarbon (PAH) compounds This study aims to determine the potential of tar waste as a disinfectant based on antibacterial activity tests and phenol coefficient tests with Salmonella typhimurium bacteria. Tar waste was tested for its antibacterial activity to determine the effective concentration between with concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% that has the potential to be an active ingredient in disinfectants. The effectiveness of the disinfectant was measured by the coefficient value of tar waste compared to 5% phenol against the Salmonella typhimurium test bacteria. If the coefficient value is equal to or greater than 1, it is said that tar waste is effectively used as a disinfectant. The results showed that the effective concentration of tar waste as a raw material for disinfectant through the antibacterial activity test was 100% with an inhibition zone diameter of 0.275556 mm in the weak category. The phenol coefficient value of 100% tar waste is 0.05. The conclusion of this study is that tar waste with a concentration of 100% is not yet effective as a raw material for disinfectant according to SNI 1842:2019.

10

Facile green synthesis of Cinnamomum tamala extract capped silver nanoparticles and its biological applications

Narath Sajina, Shankar S. Sharath, Sivan Saranya Kothaplamoottil, George Bini, Thomas T. Dennis, Sabarinath Sankarannair, Jayaprakash Sajithkumar K., Wacławek Stanisław, Padil Vinod V. T.

Ecological Chemistry and Engineering. S

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2023

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Vol. 30, nr 1

7--21

EN

The plant mediated biogenic synthesis of nanoparticles is of magnificent concern due to its eco-benign and single pot nature. Here, Cinnamomum tamala (C. tamala) aqueous leaf extract was utilised for the silver nanoparticles’ (Ag NPs) synthesis. The phytoconstituents in the leaf extract were analysed by standard methods. These metabolites, especially carbohydrate polymers reduce Ag ions to Ag NPs accompanied by a reddish-brown coloration of the reaction mixture. The visual observation of intense brown colour is the first indication of the formation of Ag NPs. Various spectro-analytical techniques further characterise the Ag NPs. The green synthesised spherical Ag NPs were crystalline with an average size of 38 nm. The Ag NPs were scrutinised for antioxidant, antimicrobial and cytotoxic activity and obtained good results. The free radical scavenging was studied by 2, 2-Diphenyl-l-picrylhydrazyl (DPPH) assay. The antibacterial activity of Ag NPs was assessed against human pathogens, and it shown to have good antibacterial potency against a wide spectrum of bacteria. The cytotoxic activity against HEK-293T (human embryonic kidney) cell line was evaluated by 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay. These potent biological activities enable C. tamala capped Ag NPs to be suitable candidates for the future applications in various fields, predominantly clinical and biomedical.

11

Effect of Annealing Treatment on (Mg17Al12) Phase Characterization and Corrosion Behavior in Different Solutions for AZ91 Alloy

Abass Marwa H., Abdulkareem Makarim H., Hussein Hussien A.

Advances in Science and Technology. Research Journal

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2023

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Vol. 17, no. 2

330--341

EN

Heat treatment is the most suitable technique for altering the microstructure and, consequently, it is possible to create the optimal balance of corrosion resistance and mechanical strength in a material by carefully regulating the conditions during the heating process. The present work aims to investigate the effect of heat treatments (annealing) at (300°C) at different times (10, 20, and 30 hr) on the magnesium alloy. How the Mg17Al12 phase influences the corrosion behavior of AZ91D magnesium alloy was quantified in different solution (SBF, Lactic and Ringer). It was able to construct an extensive range of Mg17Al12 phase volume fractions by varying the annealing period. The corrosion potential of many specimens with varied proportions of the Mg17Al12 phase was evaluated. The results of the conducted tests manifested that the material's resistance to corrosion greatly improved with an increase in the volume fraction of Mg17Al12 phase. The effect of heat treatment on the microstructure was analyzed using transmission electron microscopy and X-ray diffraction. The SEM photographs evinced that the amount of β-Mg17Al12 phase decreased significantly, with the distribution occurring at the grain boundaries and with increasing the time of annealing, resulting in a highly saturated α-grain. The XRD validated the all material peaks of phases that are present. The corrosion test behavior of AZ91 alloy in the simulated body fluid (SBF), lactic, and Ringer solutions was investigated through electrochemical measurements, the result was elucidated as measured along the Tafel slope, and the corrosion current density of all heat treated samples was lower than that of the as-cast sample. The measurement of hardness (HV) demonstrated that the hardness decreased to (64.5 HV0.5) during the heat treatment. The result antibacterial efficiency was revealed that AZ91 at 30 hr was best then as cast against the bacteria E.coli.

12

Cement typu MTA na bazie krzemianu trójwapnia wzbogaconego ZnO – ocena cytotoksyczności oraz działanie bakteriobójcze

Ciołek Lidia, Jaegermann Zbigniew, Zaczyńska Ewa, Czarny Anna, Biernat Monika, Gąsiński Arkadiusz, Pagacz Joanna, Tymowicz-Grzyb Paulina, Jastrzębska Agnieszka, Gloc Michał, Olszyna Andrzej

Szkło i Ceramika

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2022

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R. 73, nr 4

34--41

PL

W artykule przedstawiono wyniki badań in vitro dotyczące cytotoksyczności i działania bakteriobójczego materiału do stosowania w endodoncji – cementu typu MTA (ang. Mineral Trioxide Aggregate) o nowym składzie chemicznym. Cement wytworzono na bazie krzemianu trójwapnia wzbogaconego ZnO i płynu będącego 15% roztworem CaCl2 , a jako czynnik wprowadzający kontrast RTG zastosowano ZrO2 . Wytworzony cement MTA oceniono poprzez scharakteryzowanie właściwości fizykochemicznych obejmujących: czas wiązania, wytrzymałość na ściskanie, a także kontrast RTG i bioaktywność w roztworze symulującym osocze (SBF). Do zbadania wpływu ziaren ZrO2 na ilość i wielkość porów w cemencie wykorzystano technikę mikrotomografii komputerowej (µCT). Działanie cytotoksyczne cementów oceniano przez zastosowanie referencyjnej linii komórkowej L-929. Warunki hodowli komórkowej w kontakcie z badanymi materiałami lub ekstraktami z cementów oceniano za pomocą analizy obrazu lub testu kolorymetrycznego MTT. Do badania aktywności przeciwbakteryjnej wykorzystano dwa szczepy paciorkowców: Streptococcus mutans i Streptococcus sanguinis. Opracowany cement typu MTA charakteryzuje się odpowiednimi właściwościami użytkowymi i spełnia wymagania zawarte w normie PN-EN ISO 10993-5:2009 „Biologiczna ocena wyrobów medycznych, część 5: Badania cytotoksyczności in vitro”. Jednak, aby mógł być rozważany jako bezpieczny wyrób medyczny do wypełniania wstecznego kanałów korzeniowych, wymaga dalszych badań.

EN

The article presents the results of in vitro cytotoxicity and bactericidal activity of MTA-type cement (Mineral Trioxide Aggregate) for endodontics with a new chemical composition. The cement was made on the basis of ZnO-enriched tricalcium silicate and a liquid being a 15% CaCl2 solution. ZrO2 was used as an X-ray radiopacity agent in the cement. The produced MTA-type cement was assessed by characterizing the physicochemical properties including: setting time, compressive strength, as well as X-ray radiopacity and bioactivity in a simulated body fluid (SBF). Microtomography technique (µCT) was used to investigate the effect of ZrO2 grains on the number and size of pores in the cement. The cytotoxic activity of the cements was assessed by using the reference L-929 cell line. Cell culture conditions in contact with test materials or cement extracts were assessed by image analysis or MTT colorimetric test. Two strains of streptococci were used to test the antibacterial activity: Streptococcus mutans and Streptococcus sanguinis. The developed MTA cement has appropriate functional properties and meets the requirements of the PNEN ISO 10993-5:2009 standard "Biological evaluation of medical devices, Part 5: In vitro cytotoxicity tests". However, in order to be considered a safe medical device for retrograde root canal filling, it requires further research.

13

Antiadherent and antibacterial properties of TiO2-coated and TiO2:Ag-coated stainless steel orthodontic wires against S. mutans bacteria

Bącela Justyna Joanna, Kielan-Grabowska Zofia, Borak Beata, Sobieszczańska Beata, Walczuk Urszula, Kawala Beata, Zięty Anna, Detyna Jerzy, Sarul Michał

Acta of Bioengineering and Biomechanics

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2022

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Vol. 24, no. 3

107--118

EN

Conventional orthodontic treatment with stainless steel orthodontic wires may be detrimental to oral health, as it contributes to demineralized lesions and increases adhesion and bacterial biofilm formation, which contributes to cavity development. An alternative that has been investigated to reduce the side effects of orthodontic treatment is the use of coating materials with antimicrobial nanoparticles. This study aims to evaluate the antiadherent and antibacterial properties of TiO2-coated and TiO2:Ag-coated stainless steel orthodontic wires against S. mutans bacteria. Methods: In the sol–gel method, TiO2:Ag thin films were deposited on stainless steel orthodontic wires. Coated archwires were analyzed for their antibacterial and antiadherent properties. The evaluation of Streptococcus mutans adhesion to the orthodontic wires’ surface was conducted according to the type of coating used, biofilm formation assay, and measurement of the pH of the bacterial community. Results: In the microbiological test, the TiO2:Ag coatings revealed a statistically significant difference in terms of microbial adhesion and biofilm formation by Streptococcus mutans. The TiO2:Ag coating on stainless steel wire increased pH levels in the saliva environment. Conclusions: It can be concluded that antimicrobial orthodontic wires coated with silver- TiO2 nanoparticles using the sol–gel thin film are a promising choice for improving orthodontic treatment.

14

Analysis of the antibacterial properties of polycaprolactone modified with graphene, bioglass and zinc-doped bioglas

Hajduga Maciej B., Bobiński Rafał, Dutka Mieczysław, Ulman-Włodarz Izabela, Bujok Jan, Pająk Celina, Ćwiertnia Michał, Kurowska Anna, Dziadek Michał, Rajzer Izabella

Acta of Bioengineering and Biomechanics

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2021

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Vol. 23, no. 2

131--138

EN

Purpose: Innovative biomedical filaments for 3D printing in the form of short and biodegradable composite sticks modified with various additives were used to prepare biomaterials for further nasal implants. As the respiratory tract is considered to be potentially exposed to contamination during the implantation procedure there is a need to modify the implant with an antibacterial additives. The purpose of this work was to analyze the effect of biodegradable polymer – polycaprolactone (PCL) modification with various additives on its antibacterial properties. Methods: PCL filament modified with graphene (0.5, 5, 10% wt.), bioglass (0.4% wt.) and zinc-doped bioglass (0.4% wt.) were used to print spatial biomaterials using FDM 3D printer. Pure polymer biomaterials without additives were used as reference samples. The key task was to assess the antimicrobial impact of the prepared biomaterials against the following microorganisms: Staphylococcus aureus ATCC 25293, Escherichia coli ATCC 25922, Candida albicans ATCC 10231. Results: The research results point to a significant antibacterial efficacy of the tested materials against S. aureus and C. albicans, which, however, seems to decrease with increasing graphene content in the filaments. A complete lack of antibacterial efficacy against E. coli was determined. Conclusions: The tested biomaterials have important antibacterial properties, especially against C. albicans. The obtained results showed that biomaterials made of modified filaments can be successfully used in implantology, where a need to create temporary tissue scaffolds occurs.

15

Okładziny ceramiczne o właściwościach antybakteryjnych

Woźniak Zbigniew

Szkło i Ceramika

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2020

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R. 71, nr 1

11--13

PL

Artykuł opisuje przebieg prac połączonego zespołu badawczo-rozwojowego Ceramiki Paradyż Sp. z o.o. i Smart Nanotechnologies Sp. z o.o., których efektem jest opracowanie technologii okładzin ceramicznych (płytek) o właściwościach antybakteryjnych. W badaniach testowano jej wpływ na często występujących w otoczeniu przedstawicieli bakterii typu Gram-dodatnich Staphylococcus aureus oraz Gram-ujemnych Escherichia coli. Zaprezentowano wyniki badań potwierdzające możliwość kontrolowanej produkcji płytek ceramicznych o właściwościach antybakteryjnych.

EN

This article describes the workshops results of the united teams of Ceramika Paradyż Sp. z o.o. and Smart Nanotechnologies Sp. z o.o.. They invented the technology of ceramic tiles to product the items with antibacterial properties. The Staphylococcus aureus and Escherichia coli were tested during the research as some of the most frequently existed environmental bacteria. They are the representatives the two types of bacteria (G+, G-). The article presents and does confirm the possibility of the stable production ceramic tiles with antibacterial properties.

16

Synthesis of antibacterial polyurethane film and its properties

Lin Zhao, Yunyun Li, Bin Cheng, Yu Chen

Polish Journal of Chemical Technology

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2020

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Vol. 22, nr 2

50--55

EN

Polyurethane (PU) is a polymer widely used in the biomedical field with excellent mechanical properties and good biocompatibility. However, it usually exhibits poor antibacterial properties for practical applications. Efforts are needed to improve the antibacterial activities of PU films for broader application prospect and added application values. In the present work, two PU films, TDI-P(E-co-T) and TDI-N-100-P(E-co-T), were prepared. Silver nanoparticles (AgNPs) were composited into the TDI-N-100-P(E-co-T) film for better mechanical properties and antibacterial activities, and resultant PU/AgNPs composite film was systematically characterized and studied. The as-prepared PU/AgNPs composite film exhibits much better antibacterial properties than the traditional PU membrane, exhibiting broader application prospect.

17

Producing Multifunctional Cotton Fabrics Using Nano CeO2 Doped with Nano TiO2 and ZnO

Bekrani Maryam, Zohoori Salar, Davodiroknabadi Abolfazl

Autex Research Journal

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2020

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Vol. 20, no. 1

78--84

EN

Cross-link method has been used to load nano CeO2, ZnO, and TiO2 on the surface of cotton fabric. Three types of nanocomposite fabrics are prepared (cotton/CeO2, cotton/CeO2/ZnO, and cotton/CeO2/TiO2) and their properties were investigated. Field emission scanning electron microscopic (FESEM) images of the samples showed good distribution of nanomaterial, and energy dispersive X-ray spectroscopy (EDX) and X-ray fluorescence (XRF) samples proved the usage of amount of nanomaterials. On the other hand, elemental mapping was used to study the distribution of each nanomaterial separately. Antibacterial property of the samples showed excellent results against both Gram-negative and Gram-positive bacteria. Also ultraviolet (UV)-blocking of treated samples showed that all samples have very low transmission when exposed to UV irradiation.

18

Phenolic plant extract enrichment of enzymatically mineralized hydrogels

Douglas Timothy E.L, Lopez-Heredia Marco A., Pułczyńska Aleksandra, Łapa Agata, Pietryga Krzysztof, Schaubroeck David, Santos Sónia A.O., Pais Adriana, Brackman Gilles, Schamphelaere Karel de, Samal Sangram Keshari, Keppler Julia K., Bauer Jonas L, Chai Feng, Blanchemain Nicolas, Coenye Tom, Pamuła Elżbieta, Skirtach Andre G

Engineering of Biomaterials

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2019

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Vol. 22, no. 149

2--9

EN

Hydrogel mineralization with calcium phosphate (CaP) and antibacterial activity are desirable for applications in bone regeneration. Mineralization with CaP can be induced using the enzyme alkaline phosphatase (ALP), responsible for CaP formation in bone tissue. Incorporation of polyphenols, plant-derived bactericidal molecules, was hypothesized to provide antibacterial activity and enhance ALP-induced mineralization. Three phenolic rich plant extracts from: (i) green tea, rich in epigallocatechin gallate (EGCG) (herafter referred to as EGCG-rich extract); (ii) pine bark and (iii) rosemary were added to gellan gum (GG) hydrogels and subsequently mineralized using ALP. The phenolic composition of the three extracts used were analyzed by ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MSn). EGCG-rich extract showed the highest content of phenolic compounds and promoted the highest CaP formation as corroborated by dry mass percentage meassurements and ICP-OES de-termination of mass of elemental Ca and P. All three extracts alone exhibited antibacterial activity in the following order EGCG-rich > PI > RO, respectively. However, extract-loaded and mineralized GG hydro-gels did not exhibit appreciable antibacterial activity by diffusion test. In conclusion, only the EGCG-rich extract promotes ALP-mediated mineralization.

19

Biokoniugaty antybiotykow jonoforowych : cele, strategie syntezy i właściwości

Antoszczak M., Kordylas M., Huczyński A.

Wiadomości Chemiczne

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2018

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[Z] 72, 1-2

1--28

EN

Polyether ionophore antibiotics (ionophores) represent a large group of naturally- occurring lipophilic compounds which are able to form complexes with the metal cations and transport them across the lipid membranes. This process disturbs the intercellular Na+/K+ concentration gradient and intracellular pH, and leads to the mitochondrial damages, cell swelling, vacuolization and finally to apoptosis process. For this reason, ionophores are commonly used in veterinary medicine as the non-hormonal growth-promoting as well as coccidiostatic agents. In this group particularly interesting are monensin and salinomycin (Fig. 1) because of their proved anti-tumour activity, including efficiency against multidrug- -resistant cancer cells and cancer stem cells of different origin. Improved synthetic derivatives of both polyether ionophores are thus of considerable current interest. Selective derivatization of these structures whose display multiple reactive functional groups and, in the case of salinomycin, a sensitive tricyclic spiroketal ring system is however non-trivial. Even so, semi-synthetic analogs reported to date includes i.a. selective derivatization of the carboxyl group, the three hydroxyl groups, the ketone group, the alkene, and epimerization of the characteristic tricyclic salinomycin unit (for more details see: M. Antoszczak, A. Huczyński, B. Brzezinski, Wiad. Chem., 2017, 71, 629). On the other hand, as part of the original program to develop innovatory anti- -cancer pro-drugs and prompted by the idea that cancer cells may be individually effectively killed by monensin and salinomycin, a very interesting direction of research is bioconjugation of these ionophores. In this context, our review article is focused on the possible role of hybrids of both ionophore antibiotics with other biologically active substances (natural amino acids, Cinchona alkaloids, flavonoids, nucleosides) in anti-bacterial and anti-cancer treatment, and gives an overview of their properties.

20

Dichloromethane-Extract of Propolis (DEP) and DEP/PLA Electrospun Fiber Membranes

Yan T., Zhang M., Shi Y., Li Y.

Fibres & Textiles in Eastern Europe

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2018

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Vol. 26, no. 6 (132)

57--62

EN

Propolis is a waxy substance produced by the honeybee that has been used as a form of traditional medicine and natural medicine since ancient times. Propolis has a wide spectrum of alleged applications, including potential anti-infection and anti-cancer effects. The following paper used a propolis extract containing 90% ethanol solution, 70% ethanol solution, ligarine, and dichloromethane as solvents that extracted the bioactive components. The highest yield of the propolis was obtained via the 70% ethanol leaching method and dichloromethane immersion stirring method. Fourier Transform Infrared (FTIR) analysis proved that the extracted propolis with dichloromethane had the highest methylene content and the maximum types of effective propolis components. A Propolis/PLA electrospinning solution was prepared by adding PLA powder into the supernatant of the dichloromethane-extract of propolis (DEP) directly, with there being no need for purification of the propolis extract and thus reducing the loss of active ingredients. DEP/PLA nanofiber was prepared via the electrospinning process, where it was found that with additional 4% PLA, the final electrospun fiber membrane was stabilised. tStudy of the antibacterial performance of the DEP/PLA electrospun membrane showed that the membrane affected some of the antibacterial properties. It was particularly effective when inhibiting Staphylococcus aureus, but not as effective when inhibiting Escherichia coli. This electrostatic spinning membrane could be used for food preservation, wound healing, and tissue engineering.

PL

Propolis to woskowa substancja wytwarzana przez pszczołę miodną, która od starożytności była stosowana jako forma tradycyjnej medycyny i medycyny naturalnej. Propolis ma szerokie spektrum domniemanych zastosowań, w tym potencjalne działanie przeciwinfekcyjne i przeciwnowotworowe. W pracy użyto ekstraktu propolisu zawierającego 90% roztwór etanolu, 70% roztwór etanolu, ligarinę i dichlorometan jako rozpuszczalniki, które ekstrahowały składniki bioaktywne. Najwyższą wydajność propolisu uzyskano metodą wymywania 70% etanolu i metodą mieszania zanurzeniowego w dichlorometanie. Analiza w podczerwieni z transformacją Fouriera (FTIR) wykazała, że wyekstrahowany propolis z dichlorometanem miał najwyższą zawartość metylenu i dużą skuteczność. Roztwór propolis/PLA przygotowano przez dodanie proszku PLA bezpośrednio do ekstraktu z dichlorometanu propolisu (DEP), bez potrzeby oczyszczania, tym sposobem zmniejszono utraty składników aktywnych. Nanowłókno DEP/PLA zostało przygotowane w procesie elektroprzędzenia, w którym stwierdzono, że przy 4% PLA membrana z włókien elektroprzędzonych jest stabilna. Ocena skuteczności antybakteryjnej membrany DEP/PLA wykazała, że posiada ona właściwości przeciwbakteryjne. Stwierdzono zadowalającą skuteczność w hamowaniu Staphylococcus aureus, przy jednocześnie niższej skuteczności w hamowaniu Escherichia coli. Wytworzona membrana może być używana do konserwacji żywności, gojenia się ran i w inżynierii tkankowej.