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http://yadda.icm.edu.pl:80/baztech/element/bwmeta1.element.baztech-d345c362-e280-4773-91e8-3c6e33c91bc9

Czasopismo

Acta of Bioengineering and Biomechanics

Tytuł artykułu

αBSM failed as a carrier of rhBMP-2 to enhance bone consolidation in a sheep model of distraction osteogenesis

Autorzy Floerkemeier, T.  Thorey, F.  Wellmann, M.  Hurschler, C.  Budde, S.  Windhagen, H. 
Treść / Zawartość
Warianty tytułu
Języki publikacji EN
Abstrakty
EN One of the problems associated with callus distraction is a long time period needed for consolidation of the newly formed bone. The goal of this study was to determine whether percutaneous injections of rhBMP 2 in BSM would enhance bone consolidation. Methods: A unilateral tibial osteotomy combined with external stabilization was performed in 20 adult sheep. After a latency of four days, distraction was conducted for 20 days. Sheep were divided into three groups: group 1 received rhBMP-2/αBSM injections at day 23 and 30, group 2 buffer/BSM injections at day 23 and 30 and group 3 did not receive any injection. The radiographs and in-vivo torsional stiffness measurements were obtained weekly during the following 50 days. Post-mortem bone densitometry (DXA) and mechanical testing were performed. Results: In-vivo stiffness assessments, DXA values and the maximum torsional moment of the sheep tibia treated with two rhBMP-2 injections were not significantly greater than those of both control groups. Conclusions: Presented application of rhBMP-2 in BSM failed to enhance bone consolidation in distraction osteogenesis.
Słowa kluczowe
PL czynniki wzrostu   kości   test biomechaniczny   DXA  
EN rhBMP-2   growth factors   αBSM   bone consolidation   biomechanical testing   DXA  
Wydawca Oficyna Wydawnicza Politechniki Wrocławskiej
Czasopismo Acta of Bioengineering and Biomechanics
Rocznik 2017
Tom Vol. 19, nr 4
Strony 55--62
Opis fizyczny Bibliogr. 30 poz., wykr.
Twórcy
autor Floerkemeier, T.
autor Thorey, F.
  • ATOS clinic Heidelberg, Germany
autor Wellmann, M.
  • Department of Orthopaedic Surgery, Hannover Medical School, Germany
autor Hurschler, C.
  • Laboratory of Biomechanics, Hannover Medical School, Germany
autor Budde, S.
  • Department of Orthopaedic Surgery, Hannover Medical School, Germany
autor Windhagen, H.
  • Department of Orthopaedic Surgery, Hannover Medical School, Germany
Bibliografia
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Uwagi
Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).
Kolekcja BazTech
Identyfikator YADDA bwmeta1.element.baztech-d345c362-e280-4773-91e8-3c6e33c91bc9
Identyfikatory
DOI 10.5277/ABB-00946-2017-02