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Graphene based porous coatings with antibacterial and antithrombogenous function - Materials and design

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The studies considered graphene-based biomaterials dedicated for cardiovascular therapy. Reduced graphene oxide flakes were introduced into the porous structure of the polyelectrolyte based coatings. TEM analysis showed the presence of graphene flakes arranged parallel to the substrate surface, firmly connected to the porous coating. Biomaterials were subjected to a comprehensive diagnosis of the biological and material properties. The material behavior was simulated using finite element method. The coatings were deposited using layer by layer method. Mechanical analysis was done using Berkovich indenter geometry. They confirmed theoretical FEA based calculations, it was observed the coating stiffness incensement under the influence of introduced particles of graphene. The endanger of the bacteriology film formation was verified based on the E-coli and Staphylo coccus bacteria. Blood–material interaction was examined in the dynamic flow conditions. Bacteriological analysis showed reduced presence of bacteria after contact with the surface with introduced graphene flakes. Dynamic analyzes on blood showed high activation of the coagulation, strong platelets consumption and a strong immune response. It is caused by sharp edge of the single plane of the graphene flake.
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Bibliogr. 39 poz., rys., tab., wykr.
  • Institute of Metallurgy and Materials Science Polish Academy of Sciences, 25 Reymonta Street, 30-059 Cracow, Poland,
  • Department of Medicine, Jagiellonian University Medical College, 8 Skawinska Street, 31-066 Cracow, Poland
  • Institute of Metallurgy and Materials Science Polish Academy of Sciences, 25 Reymonta Street, 30-059 Cracow, Poland
  • Institute of Electronic Materials Technology, 133 Wolczynska Street, 01-919 Warsaw, Poland
  • AGH University of Science and Technology, Faculty of Mechanical Engineering and Robotics, Al. Mickiewicza 30, 30-059 Cracow, Poland
  • Czestochowa University of Technology, Faculty of Civil Engineering, 69 Dabrowskiego Street, 42-201 Czestochowa, Poland
  • Laboratoire des Matériaux et du Génie Physique Grenoble Institute of Technology – Minatec 3, Parvis Louis Néel, BP 257 38016 Grenoble Cedex 1, France
  • Institute of Metallurgy and Materials Science Polish Academy of Sciences, 25 Reymonta Street, 30-059 Cracow, Poland
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