Narzędzia help

Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
first previous next last
cannonical link button


Opto - Electronics Review

Tytuł artykułu

Ultrasensitive laser spectroscopy for breath analysis

Autorzy Wojtas, J.  Bielecki, Z.  Stacewicz, T.  Mikołajczyk, J.  Nowakowski, M. 
Treść / Zawartość
Warianty tytułu
Języki publikacji EN
EN At present there are many reasons for seeking new methods and technologies that aim to develop new and more perfect sensors for different chemical compounds. However, the main reasons are safety ensuring and health care. In the paper, recent advances in the human breath analysis by the use of different techniques are presented. We have selected non-invasive ones ensuring detection of pathogenic changes at a molecular level. The presence of certain molecules in the human breath is used as an indicator of a specific disease. Thus, the analysis of the human breath is very useful for health monitoring. We have shown some examples of diseases' biomarkers and various methods capable of detecting them. Described methods have been divided into non-optical and optical methods. The former ones are the following: gas chromatography, flame ionization detection, mass spectrometry, ion mobility spectrometry, proton transfer reaction mass spectrometry, selected ion flow tube mass spectrometry. In recent twenty years, the optical methods have become more popular, especially the laser techniques. They have a great potential for detection and monitoring of the components in the gas phase. These methods are characterized by high sensitivity and good selectivity. The spectroscopic sensors provide the opportunity to detect specific gases and to measure their concentration either in a sampling place or a remote one. Multipass spectroscopy, cavity ring-down spectroscopy, and photo-acoustic spectroscopy were characterised in the paper as well.
Słowa kluczowe
EN trace matter detection   breath analysis   diseases biomarkers   absorption spectroscopy   laser spectroscopy   multi-pass spectroscopy   MPS   cavity ring-down spectroscopy   CRDS   cavity enhanced absorption spectroscopy   CEAS   photoacoustic spectroscopy   PAS  
Wydawca Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego
Czasopismo Opto - Electronics Review
Rocznik 2012
Tom Vol. 20, No. 1
Strony 26--39
Opis fizyczny Bibliogr. 100 poz., wykr.
autor Wojtas, J.
autor Bielecki, Z.
autor Stacewicz, T.
autor Mikołajczyk, J.
autor Nowakowski, M.
1. American Thoracic Society, ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, Am. J. Respir. Crit. Care Med. 171, 912–930 (2005).
2. A. Michalski, Metrology in Medicine – Selected Problems, Military University of Technology Publishing Office, Warsaw, 2011.
3. L. Pauling, A.B. Robinson, R. Teranishi, and P. Cary, “Quantitative analysis of urine vapour and breath by gas−liquid partition chromatography”, P. Natl. Acad. Sci. USA 68, 2374–2384 (1971).
4. H. O’Neill, S.M. Gordon, M. O’Neill, R.D. Gibbons, and J.P. Szidon, “A computerized classification technique for screening for the presence of breath biomarkers in lung cancer”, Clin. Chem. 34, 1613–1618 (1988).
5. C. Wang and P. Sahay, “Breath analysis using laser spectroscopic techniques: breath biomarkers, spectral fingerprints, and detection limits”, Sensors 9, 8230–8262 (2009).
6. T. Kondo, T. Mitsui, M. Kitagawa, and Y. Nakae, “Association of fasting breath nitrous oxide concentration with gastric juice nitrate and nitrite concentrations and helicobacter pylori infection”, Digest. Dis. Sci. 45, 2054–2057 (2000).
7. R.A. Dweik, D. Laskowski, H.M. Abu−Soud, F.T. Kaneko, R. Hutte, D.J. Stuehr, and S.C. Erzurum, “Nitric oxide synthesis in the lung, regulation by oxygen through a kinetic mechanism”, J. Clin. Invest. 101, 660–666 (1998).
8. B. Enderby, D. Smith, W. Carroll, and W. Lenney, “Hydrogen cyanide as a biomarker for Pseudomonas aeruginosa in the breath of children with cystic fibrosis”, Pediatr. Pulm. 44, 142–147 (2009).
9. Z. Witkiewicz, Principles of Chromatography, Scientific−Technical Publishers (WNT), Warsaw, 2000. (in Polish)
10. W. Mueller, J. Schubert, A. Benzing, and K. Geiger, “Method for analysis of exhaled air by microwave energy desorption coupled with gas chromatography−flame ionization detection−mass spectrometry”, J. Chromatogr. B716, 27–38 (1998).
11. X. Chen, F. Xu, Y. Wang, Y. Pan, D. Lu, and P. Wang, “A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis”, Cancer 110, 835–844 (2007).
12. A. Ulanowska, T. Ligor, M. Michel, and B. Buszewski, “Hyphenated and unconventional methods for searching volatile cancer biomarkers”, Ecol. Chem. En. 17, 9–23 (2010).
15. T. Pustelny, Physical and Technical Aspects of Optoelectronic Sensors, Silesian University of Technology Publishing Office, 2005.
16. Ivanov0010.html
17. html
18. A. Bratkowski, A. Korcala, Z. Łukasik, P. Borowski, and W. Bala, “Novel gas sensor based on porous silicon measured by photovoltage, photoluminescence, and admittance spectroscopy”, Opto−Electron. Rev. 13, 35–38 (2005).
19. R. Maniewski, A. Liebert, M. Kacprzak, and A. Zbieć, “Selected application of near−infrared optical methods in medical diagnosis”, Opto−Electron. Rev. 12, 255–262 (2004).
20. J. Puton, K. Jasek, B. Siodłowski, A. Knap, and K. Wiśniewski, “Optimization of a pulsed IR source for NDIR gas analysis”, Opto−Electron. Rev. 10, 97–103 (2002).
21. M. Walczak, “Operant conditioning of dogs for detection of odour markers of cancer diseases”, PhD Dissertation, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Warsaw, Poland, 2009. (in Polish)
22. P. Kowalczyk, Physics of Molecules, Polish Scientific Publishers (PWN), Warsaw, 2000. (in Polish)
23. M.F. Merienne, A. Jenouvrier, and B. Coquart, “The NO2 absorption spectrum. I: absorption cross−sections at ambient temperature in the 300−500 nm region”, J. Atmos. Chem. 20, 281–297 (1995).
24. M.I. Mazurenka, B.I. Fawcett, J.M.F. Elks, D.E. Shallcross, and A.J. Orr−Ewing, “410−nm diode laser cavity ring−down spectroscopy for trace detection of NO2”, Chem. Phys. Lett. 367, 1–9 (2003).
25. J. Wojtas, A. Czyżewski, T. Stacewicz, and Z. Bielecki, “Detection of NO2 using cavity enhanced methods”, Opt. Appl. 36, 461–467 (2006).
26. K. Holc, Z. Bielecki, J. Wojtas, P. Perlin, J. Goss, A. Czyżewski, P. Magryta, and T. Stacewicz, “Blue tunable laser diodes for trace matter detection”, Opt. Appl. 40, 641–651 (2010).
27. T. Stacewicz, J. Wojtas, Z. Bielecki, M. Nowakowski, J. Mikołajczyk, R. Mędrzycki, and B. Rutecka, “Cavity Ring Down Spectroscopy: detection of trace amounts of matter”, Opto−Electron. Rev. 20, (2012). (in press)
29. J. Wojtas, J. Mikołajczyk, M. Nowakowski, B. Rutecka, R. Mędrzycki, and Z. Bielecki, “Appling CEAS method to UV, VIS, and IR spectroscopy sensors”, B. Pol. Acad. Sci−Te. 59, No. 4 (brak stron) (2011).
33. J.M. Chalmers, Mid−infrared Spectroscopy. Spectroscopy in Process Analysis, CRC Press LLC, 117, 1999.
35. A. O’Keefe and D.A.G. Deacon, “Cavity ring−down optical spectrometer for absorption measurements using pulsed laser sources”, Rev. Sci. Instrum. 59, 2544–2551 (1988).
36. K.W. Busch and M.A. Busch, Cavity−Ringdown Spectroscopy, an Ultratrace−Absorption Measurement Technique, ACS Symposium Series, American Chemical Society, Washington DC, 1999.
37. G. Berden and R. Engeln, Cavity Ring−Down Spectroscopy: Techniques and Applications, Wiley−Blackwell, 2009.
38. Z. Bielecki and T. Stacewicz, Optoelectronic Sensor of Nitrogen Dioxide, Analysis and Construction Requirements, Military University of Technology Publishing Office, Warsaw, 2011. (in Polish)
39. D. Romanini, A.A. Kachanov, N. Sadeghi, and F. Stoeckel, “CW−cavity ring down spectroscopy”, Chem. Phys. Lett. 264, 316–322 (1997).
40. G. Berden, R. Peeters, and G. Meijer, “Cavity ring−down spectroscopy: Experimental schemes and applications”, Int. Rev. Phys. Chem. 19, 565–607 (2000).
41. J. Ye, L.S. Ma, and J.L. Hall, “Ultrastable optical frequency reference at 064 μm using a C2HD molecular overtone transition”, IEEE T. Instrument. Meas. 46, 178–182 (1997).
42. R. Engeln, G. Berden, R. Peeters, and G. Meier, “Cavity enhanced absorption and cavity enhanced magnetic rotation spectroscopy”, Rev. Sci. Instrum. 69, 3763–3769 (1998).
43. J.D. Ayers, R.L. Apodaca, W.R. Simpson, and D.S. Baer, “Off−axis cavity ring−down spectroscopy: application to atmospheric nitrate radical detection”, Appl. Opt. 44, 7239–7242 (2005).
44. L. Menzel, A.A. Kosterev, R.F. Curl, F.K. Tittel, C. Gmachl, F. Capasso, D.L. Sivco, J.N. Baillargeon, A.L. Hutchinson, A.Y. Cho, and W. Urban, “Spectroscopic detection of biological NO with a quantum cascade laser”, Appl. Phys. B72, 859–863 (2001).
45. J.M. Herbelin, J.A. McKay, M.A. Kwok, R.H. Uenten, D.S.Urevig, D.J. Spencer, and D.J. Benard, “Sensitive measurement of photon lifetime and true reflectances in an optical cavity by a phase−shift method”, Appl. Opt. 19, 144–147 (1980).
46. F.K. Tittel, Yu. Bakhirkin, A.A. Kosterev, G. Wysocki, and S. So & R.F. Curl, “Recent advances of quantum and interband cascade laser based gas sensor technology”,
47. V. Spagnolo, R. Lewicki, L. Dong, and F. K. Tittel, “Quantum−cascade−laser−based optoacoustic detection for breath sensor applications”, IEEE 978, 332–335 (2011).
48. A. O'Keefe, “Integrated cavity output analysis of ultra−weak absorption”, Chem. Phys. Lett. 293, 331–336 (1998).
49. A. O'Keefe, J.J. Scherer, and J.B. Paul, “CW integrated cavity output spectroscopy”, Chem. Phys. Lett. 307, 343–349 (1999).
50. H. Dahnke, D. Kleine, C. Urban, P. Hering, and M. Murtz, “Isotopic ratio measurement of methane in ambient air using mid−infrared cavity leak−out spectroscopy”, Appl. Phys. B−Lasers O. 72, 121–125 (2001).
51. D. Halmer, S. Thelen, P. Hering, and M. M tz, “Online monitoring of ethane traces in exhaled breath with a difference frequency generation spectrometer”, Appl. Phys. B−Lasers O. 85, 437–443 (2006).
52. D. Halmer, G. von Basum, P. Hering, and M. Murtz, “Mid−infrared cavity leak−out spectroscopy for ultrasensitive detection of carbonyl sulphide”, Opt. Lett. 30, 2314–2316 (2005).
53. T. Starecki, Selected Aspects of Photoacoustic Instruments Optimization, BTC, Legionowo, 2009.
54. A.A. Kosterev, Y.A. Bakhirkin, R.F. Curl, and F.K. Tittel, “Quartz−enhanced photoacoustic spectroscopy”, Opt. Lett. 27, 1902–1904 (2002).
55. R.F. Curl and F.K. Tittel, “Tunable infrared laser spectroscopy”, Annu. Rep. Prog. Chem. Sect. C98, 217–270 (2002).
56. F.K. Tittel, D. Richter, and A. Fried, “Mid−infrared laser applications in spectroscopy”, Springer. Topics Appl. Phys. 89, 445–510 (2003).
57. A. Kosterev, F.K. Tittel, D. Serebryakov, A. Malinovsky, and A. Morozov, “Applications of quartz tuning fork in spectroscopic gas sensing”, Rev. Sci. Instrum. 76, 043105 (2005).
58. M. Bugajski, K. Kosiel, A. Szerling, J. Kubacka−Traczyk, I. Sankowska, P. Karbownik, A. Trajnerowicz, E. Pruszyńska Karbownik, K. Pierściński, and D. Pierścińska, “GaAs/AlGaAs (9.4 μm) quantum cascade lasers operating at 260 K”, B. Pol. Acad. Sci−Te. 58, 471–476 (2010).
60. P.C. Kamat, C.B. Roller, K. Namjou, J.D. Jeffers, A. Faramarzalian, R. Salas, and P.J. McCann, “Measurement of acetaldehyde in exhaled breath using a laser absorption spectrometer”, Appl. Opt. 46, 3969–3975 (2007).
61. C. Wang and A. Mbi, “A new acetone detection device using cavity ringdown spectroscopy at 266 nm: evaluation of the instrument performance using acetone sample solutions”, Meas. Sci. Technol. 18, 2731–2741 (2007).
62. C. Wang, A. Mbi, and M. Shepherd, “A study on breath acetone in diabetic patients using a cavity ring−down breath analyzer: Exploring correlations of breath acetone with blood glucose and glycohemoglobin A1C”, IEEE Sens. 10, 54–63 (2010).
63. C. Wang and A.B. Surampudi, “An acetone breath analyzer using cavity ring−down spectroscopy: an initial test with human subjects under various situations”, Meas. Sci. Technol. 19, 105604–105614 (2008).
64. L.R. Narasimhan, W. Goodman, and C.K.N. Patel, “Correlation of breath ammonia with blood urea nitrogen and creatinine during hemodialysis”, P. Natl. Acad. Sci. USA 98, 4617–4621 (2001).
65. U. Lachish, S. Rotter, E. Adler, and U. El−Hanany, “Tunable diode laser based spectroscopic system for ammonia detection in human respiration”, Rev. Sci. Instrum. 58, 923–927 (1987).
66. J. Manne, O. Sukhorukov, W. Jager, and J. Tulip, “Pulsed quantum cascade laser−based cavity ring−down spectroscopy for ammonia detection in breath”, Appl. Opt. 45, 9230–9237 (2006).
67. J. Manne, W. Jager, and J. Tulip, “Sensitive detection of ammonia and ethylene with a pulsed quantum cascade laser using intra and interpulse spectroscopic techniques”, Appl. Phys. B−Lasers O. 94, 337–344 (2009).
68. K.L. Moskalenko, A.I. Nadezhdinskii, and I.A. Adamovskaya, “Human breath trace gas content study by tunable diode laser spectroscopy technique”, Infrared Phys. Techn. 37, 181–192 (1996).
69. M.J. Thorpe, D. Balslev−Clausen, M.S. Kirchner, and J. Ye, “Cavity−enhanced optical frequency comb spectroscopy: application to human breath analysis”, Opt. Express 16, 2387–2397 (2008).
70. R. Lewicki, A.A. Kosterev, Y.A. Bakhirkin, D.M. Thomazy, J. Doty, L. Dong, and F.K. Tittel, “Real time ammonia detection in exhaled human breath with a quantum cascade laser based sensor”, IEEE 978, 1–2 (2009).
71. M.M.J.W. Van Herpen, A.K.Y. Ngai, S.E. Bisson, J.H.P. Hackstein, E.J. Woltering, and F.J.M. Harren, “Optical parametric oscillator−based photoacoustic detection of CO2 at 4.23 μm allows real−time monitoring of the respiration of small insects”, Appl. Phys. B−Lasers O. 82, 665–669 (2006).
72. E.R. Crosson, K.N. Ricci, B.A. Richman, F.C. Chilese, T.G. Owano, R.A. Provencal, M.W. Todd, J. Glasser, A.A. Kachanow, B.A. Paldus, T.G. Spence, and R.N. Zare, “Stable isotope ratios using cavity ring−down spectroscopy: determination of 13C/12C for carbon dioxide in human breath”, Anal. Chem. 74, 2003–2007 (2002).
73. V. Weldon, J. O'Gorman, P. Phelan, J. Hegarty, and T. Tanbun−Ek, “H2S and CO2 gas sensing using DFB laser diodes emitting at 57 μm”, Sens. Actuat. B29, 101–107 (1995).
74. G. Wysocki, M. McCurdy, S. So, D. Weidmann, C. Roller, R.F. Curl, and F.K. Tittel, “Pulsed quantum−cascade laser−based sensor for trace−gas detection of carbonyl sulphide”, Appl. Opt. 43, 6040–6046 (2004).
75. Ch. Roller, A.A. Kosterev, F.K. Tittel, K. Uehara, C. Gmachl, and D.L. Sivco, “Carbonyl sulfide detection with a thermoelectrically cooled midinfrared quantum cascade laser”, Opt. Lett. 28, 2052–2054 (2003).
76. M.R. McCurdy, Y. Bakhirkin, G. Wysocki, and F.K. Tittel, “Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser−based integrated cavity output spectroscopy”, J. Biomed. Opt. 12, 034034:1–034034:9 (2007).
77. R. Bartlome and M.W. Sigrist, “Laser based human breath analysis: D/H isotope ratio increases following heavy water intake”, Opt. Lett. 34, 866–868 (2009).
78. K.R. Parameswaran, D.I. Rosen, M.G. Allen, A.M. Ganz, and T.H. Risby, “Off−axis integrated cavity output spectroscopy with a mid−infrared interband cascade laser for real−time breath ethane measurements”, Appl. Opt. 48, B73–B79 (2009).
79. K.D. Skeldon, L.C. McMillan, C.A. Wyse, S.D. Monk, G. Gibson, C. Patterson,; T. France, C. Longbottom, and M.J. Padgett, “Application of laser spectroscopy for measurement of exhaled ethane in patients with lung cancer”, Respir. Med. 100, 300–306 (2006).
80. H. Dahnke, D. Kleine, C. Urban, P. Hering, and M. Murtz, “Isotopic ratio measurement of methane in ambient air using mid−infrared cavity leak−out spectroscopy”, Appl. Phys. B−Lasers O. 72, 121–125 (2001).
81. G. von Basum, D. Halmer, P. Hering, M. Murtz, S. Schiller, F. Mueller, A. Popp, and F. Kuehnemann, “Parts per trillion sensitivity for ethane in air with an optical parametric oscillator cavity leak−out spectrometer”, Opt. Lett. 29, 797–799 (2004).
82. C.S. Patterson, L.C. McMillan, K. Stevenson, K. Radhakrishnan, P.G. Shiels, M.J. Padgett, and K.D. Skeldon, “Dynamic study of oxidative stress in renal dialysis patients based on breath ethane measured by optical spectroscopy”, J. Breath Res. 1, 026005:1–026005:8 (2007).
83. K.D. Skeldon, C. Patterson, C.A. Wyse, G.M. Gibson, M.J. Padgett, C. Longbottom, and L.C McMillan, “The potential offered by real−time, high−sensitivity monitoring of ethane in breath and some pilot studies using optical spectroscopy”, J. Opt. A−Pure Appl. Op. 7, S376–S384 (2005).
84. A. Puiu, G. Giubileo, and C. Bangrazi, “Laser sensors for trace gases in human breath”, Int. J. Environ. A. Ch. 85, 1001–1012 (2005).
85. D.C. Dumitras, D.C. Dutu, C. Matei, A.M. Magureanu, M. Petrus, C. Popa, and V. Patachia, “Measurements of ethylene concentration by laser photoacoustic techniques with applications at breath analysis”, Rom. Rep. Phys. 60, 593–602 (2008).
86. J.H. Miller, Y.A. Bakhirkin, T. Ajtai, F.K. Tittel, C.J. Hill, and R.Q. Yang, “Detection of formaldehyde using off−axis integrated cavity output spectroscopy with an interband cascade laser”, Appl. Phys. – Laser O. 85, 391–396 (2006).
87. D. Rehle, D. Leleux, M. Erdelyi, F. Tittel, M. Fraser, and S. Friedfeld, “Ambient formaldehyde detection with a laser spectrometer based on difference−frequency generation in PPLN”, Appl. Phys. B− Laser O. 72, 947–952 (2001).
88. H. Dahnke, G. von Basum, K. Kleinermanns, P. Hering, and M. Murtz, “Rapid formaldehyde monitoring in ambient air by means of mid−infrared cavity leak−out spectroscopy”, Appl. Phys. B−Lasers O. 75, 311–316 (2002).
89. M. Angelmahr, A. Miklos, and P. Hess, “Photoacoustic spectroscopy of formaldehyde with tunable laser radiation at the parts per billion level”, Appl. Phys. B−Lasers O. 85, 285–288 (2006).
90. M. Horstjann, Y.A. Bakhirkin, A.A. Kosterev, R.F. Curl, F.K. Tittel, C.M. Wong, C.J. Hill, and R.Q. Yang, “Formaldehyde sensor using interband cascade laser based quartz−enhanced photoacoustic spectroscopy”, Appl. Phys. B−Lasers O. 79, 799–803 (2004).
91. D. Richter, A. Fried, B.P. Wert, J.G. Walega, and F.K. Tittel, “Development of a tunable mid−IR difference frequency laser source for highly sensitive airborne trace gas detection”, Appl. Phys. B−Lasers O. 75, 281–288 (2002).
92. L. Ciaffoni, R. Grilli, G. Hancock, A.J. Orr−Ewing, R. Peverall, and G.A.D. Ritchie, “3.5−μm high−resolution gas sensing employing a LiNbO3 QPM−DFG waveguide module”, Appl. Phys. B−Lasers O. 94, 517–525 (2009).
93. D. Marinov, J.M. Rey, M.G. Muller, and M.W. Sigrist, “Spectroscopic investigation of methylated amines by a cavity−ringdown−based spectrometer”, Appl. Opt. 46, 3981–3986 (2007).
94. Y.A. Bakhirkin, A.A. Kosterev, C. Roller, R.F. Curl, and F.K. Tittel, “Mid−infrared quantum cascade laser based off−axis integrated cavity output spectroscopy for biogenic nitric oxide detection”, Appl. Opt. 43, 2257–2266 (2004).
95. K. Namjou, C.B. Roller, T.E. Reich, J.D. Jeffers, G.L. McMillen, P.J. McCann, and M.A. Camp, “Determination of exhaled nitric oxide distributions in a diverse sample population using tunable diode laser absorption spectroscopy”, Appl. Phys. B−Lasers O., 85, 427–435 (2006).
96. L. Menzel, A.A. Kosterev, R.F. Curl, F.K. Tittel, C. Gmachl, F. Capasso, D.L. Sivco, J.N. Baillargeon, A.L. Hutchinson, A.Y. Cho, and W. Urban, “Spectroscopic detection of biological NO with a quantum cascade laser”, Appl. Phys. B−Lasers O. 72, 859–863 (2001).
97. A.A. Kosterev, A.L. Malinovsky, F.K. Tittel, C. Gmachl, F. Capasso, D.L. Sivco, J.N. Baillargeon, A.L. Hutchinson, and A.Y. Cho, “Cavity ringdown spectroscopic detection of nitric oxide with a continuous−wave quantum−cascade laser”, Appl. Opt. 40, 5522–5529 (2001).
98. C. Roller, K. Namjou, J.D. Jeffers, M. Camp, A. Mock, P.J. McCann, and J. Grego, “Nitric oxide breath testing by tunable−diode laser absorption spectroscopy: application in monitoring respiratory inflammation”, Appl. Opt. 41, 6018–6029 (2002).
99. K. Namjou, C.B. Roller, and G. McMillen, “Breath analysis using mid infrared tunable laser spectroscopy”, Proc. 6th Ann. IEEE Conf. on Sensors, Atlanta, GA, 1337–1340 (2007).
100. K. Heinrich, T. Fritsch, P. Hering, and M. Murtz, “Infrared laser−spectroscopic analysis of 14NO and 15NO in human breath”, Appl. Phys. B−Lasers O. 95, 281–286 (2009).
Kolekcja BazTech
Identyfikator YADDA bwmeta1.element.baztech-article-BWA0-0051-0055