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The aim of our research was to investigate the genotoxic effects of cobalt chloride and copper chloride in mouse bone marrow cells using the micronucleus (MN) assay. The three different concentrations of cobalt chloride (11.2, 22.5 and 45 mg kg-1) and copper chloride (1.17, 2.35 and 4.70 mg kg-1) were injected intraperitoneally to mice for 24 and 48 hours. It was observed that both of these heavy metals induced a signifi cant increase in frequency of micronucleated polychromatic erythrocytes (MNPCE) at different concentrations in mice for 24 and 48 hours when compared with the control. Furthermore, the signifi cant reduction for the polychromatic erythrocyte/normochromatic erythrocyte (PCE/NCE) ratio which is indicative of bone marrow cytotoxicity was observed in bone marrow cells which were treated with copper chloride at all concentrations for 24 and 48 hours. No reduction of the PCE/NCE ratio was observed both 24 and 48 hours after all the doses of cobalt chloride tested as compared to the negative control. These results lead us to the conclusion that copper chloride may have genotoxic and cytotoxic properties due to induction in the frequency of MN and a reduction in PCE/NCE ratio in bone marrow cells of mice, whereas cobalt chloride induced only genotoxic effect in mice bone marrow.
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Tom
Strony
75--82
Opis fizyczny
Bibliogr. 56 poz., tab., wykr.
Twórcy
autor
autor
autor
- Duzce University, Beekeeping Research Development and Application Center, 81620 Duzce, Turkey, pinargocrasgele@gmail.com
Bibliografia
- [1] Aaron, C.S., Sorg, R., & Zimmer D. (1989). The mouse bone marrow micronucleus test: evaluation of 21 drug candidates, Mutation Research, 223, 129-140.
- [2] Agarwal, K., Sharma, A., & Talukder, G. (1990). Clastogenic effects of copper sulfate on the bone marrow chromosomes of mice in vivo, Mutation Research, 243 (1), 1-6.
- [3] Beijer, K., & Jernelov, A. (1986). Sources, transport and transformation of metals in the environment, [in:] Friberg L, Nordberg GF, Vouk VB (eds) Handbook on the toxicology of metals (pp. 68-84). Elsevier, Amsterdam 1986.
- [4] Beyersmann, D., & Hartwig, A. (2008). Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms, Arch. Toxicol., 82, 493-512.
- [5] Bhunya, S.P., & Pati, P.C. (1987). Genotoxicity of an inorganic pesticide, copper sulphate in mouse in vivo test system, Cytologia, 52, 801-808.
- [6] Bhunya, S.P., & Jena, G.B. (1996). Clastogenic effect of copper sulphate in chick in vivo test system, Mutation Research, 367 (2), 57-63.
- [7] Chemwatch. (2010). Material Safety Data Sheet, Section 11 - Toxicological Information, NC317TCP, 23-3153, 6.
- [8] Cicchetti, R., Bari, M., & Argentin, G. (1999). Induction of micronuclei in bone marrow by two pesticides and their differentiation with CREST staining: an in vivo study in mice, Mutation Research, 439, 239-248.
- [9] De Boeck, M., Kirsch-Volders, M., & Lison, D. (2003a). Cobalt and antimony: genotoxicity and carcinogenicity, Mutation Research, 533 (1-2), 135-152.
- [10] De Boeck, M., Lombaert, N., De Backer, S., Finsy, R., Lison, D., & Kirsh-Volders, M. (2003b). In vitro effects of different combinations of cobalt and metallic carbide particles, Mutagen, 18, 177-186.
- [11] Demerec, M., Bertani, G., & Flint, J. (1951). A survey of chemicals for mutagenic action on E. coli, Am. Nat., 85, 119-136.
- [12] Denizau, F., & Marion, M. (1989). Genotoxic effects of heavy metals in rat hepatocytes, Cell Biol. Toxicol., 5, 15-25.
- [13] Diagomanolin, V., Farhang, M., Ghazi-Khansari, M., & Jafarzadeh, N. (2004). Heavy metals (Ni, Cr, Cu) in the Karoon waterway river, Iran Toxicol. Lett., 151 (1), 63-67.
- [14] EPA. (1996). Health Effects Test Guidelines. OPPTS 870.5395 In Vivo Mammalian Cytogenetic Tests: Erythrocyte Micronucleus Assay. 712-C-96-226.
- [15] Fahmy, M.A., & Aly, F.A.E. (2000). In vivo and in vitro studies on the genotoxicity of cadmium chloride in mice, J. App. Toxic., 20, 231-238.
- [16] Feng, S., Wang, X., Wei, G., Peng, P., Yang, Y., & Cao, Z. (2007). Leachates of municipal solid waste incineration bottom ash from Macao: Heavy metal concentrations and genotoxicity, Chem., 67 (6), 1133-1137.
- [17] Gabbianelli, R., Lupidi, G., Villarini, M., & Falcioni, G. (2003). DNA Damage Induced by Copper on Erythrocytes of Gilthead Sea Bream Sparus aurata and Mollusk Scapharca inaequivalvis, Arch. Environ. Contam. Toxicol., 45, 350 -356.
- [18] Garrett, N.E., & Lewtas, J. (1983). Cellular toxicity in Chinese hamster ovary cells culture I, Environ. Res., 32, 455-465.
- [19] Guecheva, T., Henriques, J.A.P., & Erdtmann, B. (2001). Genotoxic effects of copper sulphate in freshwater planarian in vivo, studied with single-cell gell test (comet assay), Mutation Research, 497, 19-27.
- [20] Hall, J.L. (2002). Cellular mechanisms for heavy metal detoxification and tolerance, J. Exp. Bot., 53, 1-11.
- [21] Hartmann, A., & Speit, G. (1994). Comparative investigations of the genotoxic effects of metals in the single cell gell (SCG) assay and the sister chromatid exchange (SCE) test, Environ. Mol. Mutagen., 23, 299-305.
- [22] Hartwig, A. (1995). Current aspects in metal genotoxicity, Bio. Metals, 8, 3-11.
- [23] Heidelberger, C., Freeman, A.E., Pienta, R.J., Sivak, A., Bertram, J.S., Casto, B.C., Dunkel, V.C., Francis, M.W., Kakunaga, T., Little, J.B., & Schechtman, L.M. (1983). Cell transformation by chemical agents - a review and analysis of the literature: a report of the US, Environmental Protection Agency Gene-Tox Program. Mutation Research, 114 (3), 283-385.
- [24] International agency for research on cancer (IARC). (1991). Chlorinated drinking water; chlorination by products; some other halogenated compounds; cobalt and cobalt compounds. IARC monographs on the evaluation of carcinogenic risks to humans, 52 (pp. 363-472), IARC, Lyon 1991.
- [25] International agency for research on cancer (IARC). (2003). Cobalt in hard metals and cobalt sulfate, gallium arsenide, inidium phosphide and vanadium pentoxide. IARC monographs on the evaluation of carcinogenic risks to humans, 86 (pp. 119-237) IARC, Lyon 2006.
- [26] Katnoria, J.K., Arora, S., &. Nagpal, A. (2008). Genotoxic potential of agricultural soils of amritsar, AsianJ. Sci. Res., 1 (2), 122-129.
- [27] Knasmuller, S., Gottmann, E., Steinkellner, H., Fomin, A., Pickl, C., Paschki, A., God, R., & Kundi, M. (1998). Detection of genotoxic effects of heavy metal contaminated soils with plant bioassays, Mutation Research, 420, 37-48.
- [28] Kovalchuk, O., Titov, V., Hohn, B., & Kovalchuk, I. (2001). A sensitive transgenic plant system to detect toxic inorganic compounds in the environment, Nat. Biotech., 19, 568-572.
- [29] Kuo, H.W., & Wu, M.L. (2002). Effects of chromic acid exposure on immunological parameters among electroplating workers, Int. Arch. Occup. Environ. Health, 75, 186-190.
- [30] Law, L.W. (1938). The effects of chemicals on the lethal mutation rate in Drosophilia melanogaster, Proc. Natl. Acad. Sci. USA, 24, 546-550.
- [31] Maksymiec, W. (1997). Effect of copper on cellular processes in higher plants, Photosyn., 34 (3), 321-342.
- [32] Marzin, D.R., & Phi, H.V. (1985). Study of the mutagenicity of metal derivatives with Salmonella typhimurium, Mutation Research, 155, 49-51.
- [33] National Toxicology Program (NTP). (1998). Toxicology and carcinogenesis studies of cobalt sulfate heptahydrate in F334/N rats and B6C3F1 mice (inhalation studies), NTP Technical Report 507, USA: Research Triangle Park, NC, 1998.
- [34] NICNAS. (2003). Existing Chemicals Information Sheet, GPO Box 58, Australia: Sidney NSW, 2003.
- [35] Nishioka, H. (1975). Mutagenic activities of metal compounds in bacteria, Mutation Research, 31, 185-189.
- [36] Obiakor, M.O., Okonkwo, J.V., Ezeonyejiaku, C.D., & Ezenwelu, C.O. (2010). Genotoxicology: Single and joint action of copper and zinc to Synodontis clarias and Tilapia nilotica, J. Appl. Sci. Environ. Manage., 14 (3), 59-64.
- [37] Olivier, P., & Marzin, D. (1987). Study of the genotoxic potential of 48 inorganic derivatives with the SOS chromotest, Mutation Research, 189, 263-269.
- [38] Pra, D., Franke, S.I.R., Giulian, R., Yoneama, M.L., Dias, J.F., Erdtmann, B., & Henriques, J.A.P. (2008). Genotoxicity and mutagenicity of iron and copper in mice, Biomet., 21, 289-297.
- [39] Saeedi Saravi, S.S., Karami, S., Karami, B., & Shokrzadeh, M. (2009). Toxic effects of cobalt chloride on hematological factors of common carp (Cyprinus carpio), Biol. Trace Elem. Res., 132, 144-152.
- [40] Saleha, B.B., Ishaq, M., Danadevi, K., Padmavathi, P., & Ahuja, Y.R. (2004). DNA damage in leukocytes of mice treated with copper sulfate, Food Chem. Toxicol., 42 (12), 1931-1936.
- [41] Schmid, W. (1975). The micronucleus test, Mutation Research, 31, 9-15.
- [42] Schutzendubel, A., & Polle, A. (2002). Plant responses to abiotic stresses: heavy metal-induced oxidative stres and protection by mycorrhization, J. Exp. Bot., 53, 1351-1365.
- [43] Sideris, E.G., Charalambous, S.C., Tsolomyty, A., & Katsaros, N. (1988). Mutagenesis, carcinogenesis and the metal elements - DNA interaction, Prog. Clin. Biol. Res., 259, 13-25.
- [44] Sigma-Aldrich. (2006). Material Safety Data Sheet, 2006, www.sigma-aldrich.com (29/Aug/2006).
- [45] Singh, I. (1983). Induction of reverse mutation and mitotic gene conversion by some metal compounds in Saccharomyces cerevisiae, Mutation Research,117, 149-152.
- [46] Sipczuk-Walczak, H., Matczak, W., Raźniewska, G., & Szymczak, M. (2005). Neurologic and neurophysiologic examinations of workers occupationally exposed to aliminium, Med. Pr., 56, 9-17.
- [47] Sirover, M.A., & Loeb, L.A. (1976). Infidelity of DNA synthesis in vitro: Screening for potential metal mutagens of carcinogens, Sci., 94, 1434-1436.
- [48] Sora, S., Carbone, M.L.A., Pacciarini, M., &. Magni, G.E. (1986). Disomic and diploid meiotic products induced in Saccharomyces cerevisiae by the salts of 27 elements, Mutagen., 1 (1), 21-28.
- [49] Souguir, D., Ferjani, E., Ledoigt, G., & Goupil, P. (2008). Exposure of Vicia faba and Pisum sativum to copper-induced genotoxicity, Protoplas., 233, 203-207.
- [50] Tinwell, H., & Ashby J. (1990). Inactivity of copper sulphate in a mouse bone-marrow micronucleus assay, Mutation Research, 245 (3), 233-236.
- [51] Tshiashala, M.D., Kabengele, K., & Lumu, B.M. (1990). Trace element determination in scalp hair of people working at a copper smelter, Biol. Trace Elem. Res., 26-27, 287-294.
- [52] Tso, W.W., & Fung, W.P. (1981). Mutagenicity of metallic cations, Toxicol. Lett., 8, 195-200.
- [53] Viroj, W. (2008). Minor heavy metal: A review on occupational and environmental intoxication, Indian J. Occ. Environ. Med., 12 (3), 116-121.
- [54] Wong, P.K. (1988). Mutagenicity of heavy metals, Bull. Environ. Contam. Toxicol., 40, 597-603.
- [55] Yildiz, M., Cigerci, I.H., Konuk, M., Fidan, A.F., & Terzi, H. (2009). Determination of genotoxic effects of copper sulphate and cobalt chloride in Allium cepa root cells by chromosome aberration and comet assays, Chem., 75 (7), 934-938.
- [56] Yruela, I. (2005). Copper in plants, Braz. J. Plant Phsiol., 17(1), 145-156.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUS8-0028-0022