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http://yadda.icm.edu.pl:80/baztech/element/bwmeta1.element.baztech-article-BUJ7-0015-0088

Czasopismo

Polish Journal of Chemistry

Tytuł artykułu

Binding of Cytidine-5'-monophosphate with Human Serum Albumin: Spectroscopic and Molecular Modeling Studies

Autorzy Cui, F. L.  Yan, Y. H.  Zhang, Q. Z.  Du, J.  Yao, X. J.  Qu, G. R.  Lu, Y. 
Treść / Zawartość
Warianty tytułu
Języki publikacji EN
Abstrakty
EN The binding of cytidine-5’-monophosphate (CMP) to human serum albumin (HSA) was investigated by fluorescence spectroscopy in combination with molecular modeling under simulation of physiological conditions. The quenching mechanism was suggested to be static according to the fluorescence measurement. The thermodynamic parameters: enthalpy change (DeltaH) and entropy change (DeltaS) were calculated to be –5.09 kJ/mol and 73.00 J mol–1 K–1 according to the Vant’Hoff equation. These data suggest that hydrophobic inter actions are the predominant intermolecular forces stabilizing the complex. Experimental results are in agreement with the results obtained by molecular modeling study. In addition, the effects of commonions on the binding constants were also studied at room temperature.
Słowa kluczowe
EN cytidine-5'-monophosphate (CMP),   human serum albumin (HSA)   fluorescence spectroscopy   synchronous fluorescence spectrum   molecular modeling  
Wydawca Polskie Towarzystwo Chemiczne
Czasopismo Polish Journal of Chemistry
Rocznik 2009
Tom Vol. 83, nr 10
Strony 1783--1795
Opis fizyczny Bibliogr. 34 poz., rys.
Twórcy
autor Cui, F. L.
autor Yan, Y. H.
autor Zhang, Q. Z.
autor Du, J.
autor Yao, X. J.
autor Qu, G. R.
autor Lu, Y.
  • School of Chemistry and Environmental Science, Key Laboratory for Yellow River and Huai he River Water Environment and Pollution Control Ministry of Education, Henan Normal University, Xinxiang 453007, P.R. China, cuifl718@hotmail.com
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