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Polish Journal of Chemistry

Tytuł artykułu

On the Influence of Low-Frequency Magnetic Field Disturbances on Basic High Resolution NMR Experiments

Autorzy Kazimierczuk, K.  Koźmiński, W. 
Treść / Zawartość
Warianty tytułu
Konferencja 1st Symp. on NMR in Chemistry, Biology and Medicine; 8-10 Semptember, Warsaw, Poland. Issue dedicated to honour Prof. Witanowski
Języki publikacji EN
EN CDPcholine (citicoline, CDPCho) shows beneficial effects in various Central Nervous System (CNS) injury models and neurodegenerative diseases. Previous studies demonstrate conflictingMagnetic Resonance Spectroscopy (MRS) reports regarding the impact of different choline-containing compounds and its doses on brain metabolites. This preliminary study was designed to evaluate concentration changes of brain MR-visible metabolites following intravenous CDPCholine. Twelve healthy rats treated with CDPCholine in three subsequent doses of 1gram/kg eachwere examined using 1Hand 31P MRS in vivo. Following intravenous CDPCholine administration there was a statistically significant increase of the Cho/Cr ratio after first CDPCholine injection. The evidence of CDPcholine influence on brain metabolites has been shown.
Słowa kluczowe
EN CDP-choline   choline   cerebral metabolism   Magnetic Resonance Spectroscopy  
Wydawca Polskie Towarzystwo Chemiczne
Czasopismo Polish Journal of Chemistry
Rocznik 2006
Tom Vol. 80, nr 7
Strony 1119--1124
Opis fizyczny Bibliogr. 10 poz., rys.
autor Kazimierczuk, K.
autor Koźmiński, W.
  • H. Niewodniczański Institute of Nuclear Physics PAS, Radzikowskiego 152, 31-342 Kraków, Poland
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Kolekcja BazTech
Identyfikator YADDA bwmeta1.element.baztech-article-BUJ6-0007-0011