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http://yadda.icm.edu.pl:80/baztech/element/bwmeta1.element.baztech-article-BUJ3-0006-0040

Czasopismo

Polish Journal of Chemistry

Tytuł artykułu

Synthesis and In Vitro Cytotoxic Activity of Novel 6-Chloro-1,1-dioxo-1,4,2-benzodithiazin-3-ylhydrazine Derivatives

Autorzy Pomarancka, E.  Bednarski, P.  Grunert, R.  Brzozowski, Z.  Lach, J. 
Treść / Zawartość
Warianty tytułu
Języki publikacji EN
Abstrakty
EN The syntheses of 1-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)-4-hydroxysemicarbazides 11-19, hydroxybenzaldehyde N-(6-chloro-7-methyl-1,1-dioxo-1,4,2- benzodithiazin-3-yl)hydrazones 21-24 and 8-chloro-2-(1-naphthylamino)-5,5- dioxo[1,2,4]triazolo[2,3-b][1,4,2]benzodithiazine-7-carbonitrile (26) are described. All compounds were tested for their in vitro cytotoxic potency against 12 human cancer cell lines at the Institute of Pharmacy, University of Greifswald. The compounds 11-19 were inactive, whereas 22 and 24 exhibited weak tumor growth inhibitory properties. The compound 26 was screened at the National Cancer Institute and showed reasonable anticancer activity.
Słowa kluczowe
EN 6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-ylhydrazine derivatives   cytotoxic activity   syntheses  
Wydawca Polskie Towarzystwo Chemiczne
Czasopismo Polish Journal of Chemistry
Rocznik 2006
Tom Vol. 80, nr 3
Strony 429--438
Opis fizyczny Bibliogr. 29 poz.
Twórcy
autor Pomarancka, E.
autor Bednarski, P.
autor Grunert, R.
autor Brzozowski, Z.
autor Lach, J.
  • Department of Chemical Technology of Drugs, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland
Bibliografia
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