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http://yadda.icm.edu.pl:80/baztech/element/bwmeta1.element.baztech-article-BPBB-0009-0005

Czasopismo

Acta of Bioengineering and Biomechanics

Tytuł artykułu

Formation and preclinical evaluation of a new alloplastic injectable bone substitute material

Autorzy Bojar, W.  Kucharska, M.  Bubak, G.  Ciach, T.  Koperski, Ł.  Jastrzębski, Z.  Gruber, B.M.  Krzysztoń-Russjan, J.  Marczewska, J.  Anuszewska, E.  Drozd, E.  Brynk, T. 
Treść / Zawartość http://www.actabio.pwr.wroc.pl/acta.php
Warianty tytułu
Języki publikacji EN
Abstrakty
EN Alloplastic bone substitute materials are raising some more interest as an alternative for autologic transplants and xenogenic materials especially in oral surgery over the last few years. These non-immunogenic and completely resorbable biomaterials are the basis for complete and predictable guided bone regeneration. In the majority of cases, such a material is chosen because of its convenient application by surgeons. The main objective of our project was to design and fabricate an osteoconductive, injectable and readily tolerable by human tissues biomaterial for guided bone regeneration. For this purpose, a self-setting composite consisting of chitosan/tricalcium phosphate microparticles and sodium alginate was made. The material obtained was characterized by microsphere and agglomerate morphology and microstructure. Its features relating to setting time and mechanical properties were precisely investigated. Our material was also evaluated according to PN-EN ISO 10993 Biological evaluation of medical devices, i.e., the in vitro tests for genotoxicity and cytotoxicity were conduced. Then, the following examinations were performed: subchronic systemic toxicity, skin sensitization, irritation and delayed-type hypersensitivity and local effects after implantation. The material tested showed a high degree of cytocompatibility, fulfilled the requirements of International Standards and seemed to be a "user friendly" material for oral surgeons.
Słowa kluczowe
EN alginate   bone substitute material   chitosan   guided bone regeneration   beta-tricalcium phosphate  
Wydawca Oficyna Wydawnicza Politechniki Wrocławskiej
Czasopismo Acta of Bioengineering and Biomechanics
Rocznik 2012
Tom Vol. 14, nr 1
Strony 39--44
Opis fizyczny Bibliogr. 8 poz., rys.
Twórcy
autor Bojar, W.
autor Kucharska, M.
autor Bubak, G.
autor Ciach, T.
autor Koperski, Ł.
autor Jastrzębski, Z.
autor Gruber, B.M.
autor Krzysztoń-Russjan, J.
autor Marczewska, J.
autor Anuszewska, E.
autor Drozd, E.
autor Brynk, T.
Bibliografia
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[2] AUGST A.D., KONG H.J., MOONEY D.J., Alginate hydrogels as biomaterials, Macromol. Biosci., 2006, 623–633.
[3] ZHENSHENG L., HASSNA R., RAMAYA, KIP D., HAUCHB, DEMIN XIAOC, MIQIN ZHANGA, Chitosan-alginate hybrid scaffolds for bone tissue engineering, Biomaterials, 2005, 26(18), 3919–1928.
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[5] KIM I.Y., SEO S.J., MOON H.S., YOO M.K., PARK I.Y., KIM B.C., CHO C.S., Chitosan and its derivatives for tissue engineering applications, Biotechnol. Adv., 2008, 26(1), 1–21.
[6] KHOR E., LIM L.Y., Implantable applications of chitin and chitosan, Biomaterials, 2003, 24(13), 2339–2349.
[7] RAVI KUMAR M.N.V., MUZZARELLI R.A.A. et al., Chitosan chemistry and pharmaceutical perspectives, Chem. Rev., 2004, 104, 12, 6017–6084.
[8] BOJAR W., MARCZEWSKA J., ANUSZEWSKA E., KARWICKA E., Cytotoxicity and mutagenicity of N2 cement – root canal filling material, Adv. Clin. Exp. Med., 2009, 18, 6, 615–621.
Kolekcja BazTech
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