Quantitative determination of pentoxifylline in human plasma
Wybrane pełne teksty z tego czasopisma
A rapid, optimized, and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for deter-mination of pentoxifylline in human plasma. The analyte was extracted from the plasma with dichloromethane after addition of 0.2 mL 1 M NaOH. HPLC separation was performed on a C18 analytical column (250 mm × 4 mm i.d.) with acetonitrile–water, 45:55 (v/v), as mobile phase. Spectro-photometric detection was performed at 275 nm. Calibration graphs were linear from 25 to 1000 ng mL-1 pentoxifylline. Recovery of the drug from human plasma was 92.1%, and the detection limit was 20 ng mL-1.
Bibliogr. 15 poz., rys., tab.
-  H.R. Dettelbach and D.M. Aviado, J. Clin. Pharmacol., 25, 8 (1985)
-  M. Abramowicz, Med. Lett. Drugs Ther., 26, 103 (1984)
-  B. Beermann, R. Ings, J. Mansby, J. Chamberlain, and A. McDonald, Clin. Pharmacol. Ther., 37, 25 (1985)
-  D.M. Aviado and J.M. Porter, Pharmacotherapy, 4, 297 (1984)
-  J.L. Ambrus, J.M. Anain, S.M. Anain, P.M. Anain, S. Stadler, P. Mitchell, J.A. Brobst, B.L. Cobert, and J.P. Savitsky, Clin. Pharmacol. Ther., 48, 50 (1990)
-  R. Muller and F. Lehrach, Curr. Med. Res. Opin., 7, 253 (1981)
-  C.D. Nicholson, Psychopharmacology, 102, 147 (1990)
-  R.V. Smith, E.S. Waller, J.T. Doluisio, M.T. Bauza, S.K. Puri, I. Ho, and H.B. Lassman, J. Pharm. Sci., 75, 1 (1986)