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Non-uniform viscosity caused by red blood cell aggregation may affect NO concentration in the microvasculature

Autorzy
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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Aggregation of red blood cells in the micro vasculature may affect blood viscosity in the vessel. The purpose of this study was to investigate the potential effect of non-uniform viscosity caused by red blood cell (RBC) aggregation on nitric oxide (NO) concentration and distribution. A 3-D multi-physics model was established to simulate the production, transport and consumption of NO. Two non-uniform viscosity models caused by RBC aggregation were investigated: one assuming a linear and the other a step hematocrit distribution. In addition, the effect of the thickness of the plasma layer was tested. Simulation results demonstrate that non-uniform viscosity caused by RBCs aggregation influences NO concen-tration distribution. Compared with the uniform viscosity model, NO concentration using non-uniform viscosity is lower than that using uniform viscosity. Moreover, NO concentration calculated from the step hematocrit model is higher than that calculated from the linear hematocrit model. NO concentrations in the endothelium and the vascular wall decrease with the decline of the thickness of the plasma layer. The relative decrease differs between the linear and the step model. Our results suggest that non-uniform viscosity caused by red blood cell aggregation affects nitric oxide distribution in the micro vasculature. If uniform viscosity is assumed when performing numerical simulations, NO concentration values may be overestimated.
Twórcy
autor
  • Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China, qht@buaa.edu.cn
autor
  • Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
autor
  • School of Biomedical Engineering, Science and Health Systems, Drexel University, United States
Bibliografia
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  • [6] Chen X, Jaron D, Barbee KA, Buerk DG. The influence of radial RBC distribution, blood velocity profiles, and glycocalyx on coupled NO/O2 transport. J Appl Physiol 2006;100:482–92.
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  • [17] Long DS, Smith ML, Pries AR, Klaus L, Damiano ER. Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution. Proc Natl Acad Sci U S A 2004;101:10060–5.
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  • [19] Chen X, Buerk D, Barbee K, Jaron D. A model of NO/O2 transport in capillary-perfused tissue containing an arteriole and venule pair. Ann Biomed Eng 2007;35:517–29.
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Uwagi
PL
Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).
Typ dokumentu
Bibliografia
Identyfikator YADDA
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