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Przegląd rodzajów chiralnych faz stacjonarnych oraz możliwości ich zastosowań w chromatografii cieczowej

Autorzy Śliwka-Kaszyńska, M.  Momotko, M.  Szarmańska, J.  Boczkaj, G.  Kamiński, M. 
Treść / Zawartość
Warianty tytułu
EN Types of chiral stationary phases and its applications to liquid chromatography (LC) – a mini review
Języki publikacji PL
Abstrakty
PL Chromatograficzne rozdzielanie związków optycznie czynnych ma ogromne znaczenie nie tylko w przemyśle farmaceutycznym, ale i agrochemicznym, a także w badaniach naukowych różnego rodzaju. W niniejszym opracowaniu scharakteryzowano komercyjnie dostępne chiralne fazy stacjonarne na bazie, cyklodekstryn, polisacharydów, makrocyklicznych antybiotyków, eterów koronowych, a także fazy proteinowe, ligandowymienne, jonowymienne oraz fazy typu Pirkle’a. Omówiono podstawowe właściwości fizyczne i chemiczne w/w faz stacjonarnych, przedstawiono przykładowe ich struktury, mechanizmy chiralnego rozpoznania oraz podstawowe zastosowania. Opisano również warunki chromatograficznego rozdzielania chiralnego dla wybranych farmaceutyków i pestycydów.
EN Importance of chromatographic enantioseparations in the pharmaceutical and agrochemical industries is still increasing. In this paper the chiral stationary phases, including cyclodextrins, polysaccharides, macrocyclic antibiotics, crown ethers, proteins, ligand-exchange, Pirkle-type and ion exchange phases is discussed. For all types of chiral stationary phases, the basic physical and chemical properties are discussed, as well as the structure and the possible chiral recognition mechanisms. The basic applications of this phases are also described. Chromatographic conditions for chiral separation of selected active pharmaceutical ingredients and pesticides are reviewed.
Słowa kluczowe
PL chiralne rozdzielenie   chiralne fazy stacjonarne (CSP)   chromatografia cieczowa(LC)  
EN chiral separation   Chiral Stationary Phases (CSP)   Liquid Chromatography (LC)  
Wydawca Publishing House of Siedlce University of Natural Sciences and Humanities
Czasopismo Camera Separatoria
Rocznik 2015
Tom Vol. 7, No. 2
Strony 99--128
Opis fizyczny Bibliogr. 82 poz., rys., tab.
Twórcy
autor Śliwka-Kaszyńska, M.
autor Momotko, M.
  • Katedra Inżynierii Chemicznej i Procesowej, Wydział Chemiczny, Politechnika Gdańska
autor Szarmańska, J.
  • Katedra Inżynierii Chemicznej i Procesowej, Wydział Chemiczny, Politechnika Gdańska
autor Boczkaj, G.
  • Katedra Inżynierii Chemicznej i Procesowej, Wydział Chemiczny, Politechnika Gdańska
autor Kamiński, M.
  • Katedra Inżynierii Chemicznej i Procesowej, Wydział Chemiczny, Politechnika Gdańska, markamin@pg.gda.pl
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