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Acta of Bioengineering and Biomechanics

Tytuł artykułu

Physicochemical properties of the novel biphasic hydroxyapatite–magnesium phosphate biomaterial

Autorzy Pijocha, D.  Zima, A.  Paszkiewicz, Z.  Ślósarczyk, A. 
Treść / Zawartość
Warianty tytułu
Języki publikacji EN
EN Besides high-temperature calcium phosphates (CaPs), low-temperature calcium phosphate bone cements (CPCs), due to excellent biological properties: bioactivity, biocompability and osteoconductivity, are successfully used as bone substitutes. However, some disadvantages, related mainly to their low resorption rate and poor mechanical properties result in limited range of applications of these implant materials to non-loaded places in the skeletal system. To overcome this problem, magnesium phosphate cements (MPCs) with high strength have been considered as biomaterials. The main disadvantage of MPCs is that the acid-base setting reaction is an exothermic process that must be strictly controlled to avoid tissue necrosis. In this work, a new composite bone substitute (Hydroxyapatite Magnesium Phosphate Material – HMPM) based on hydroxyapatite (HA) and magnesium phosphate cement (MPC) with sodium pyrophosphate applied as a retardant of setting reaction was obtained. Its setting time was adequate for clinical applications. Combining properties of HA and MPC has made it possible to obtain microporous (showing bimodal pore size distribution in the range of 0.005–1.700 micrometers) potential implant material showing good surgical handiness and sufficient mechanical strength. Effectiveness of sodium pyrophosphate as a retardant of exothermic setting reaction of the new cement formulation was confirmed. After setting and hardening, the material consisted of hydroxyapatite and struvite as crystalline phases. Unreacted magnesium oxide was not detected.
Słowa kluczowe
PL kompozyty   hydroksyapatyt   materiałoznawstwo  
EN composite   bone substitute   hydroxyapatite   magnesium phosphate cement  
Wydawca Oficyna Wydawnicza Politechniki Wrocławskiej
Czasopismo Acta of Bioengineering and Biomechanics
Rocznik 2013
Tom Vol. 15, nr 3
Strony 53--63
Opis fizyczny Bibliogr. 38 poz., rys., tab., wykr.
autor Pijocha, D.
  • AGH – University of Science and Technology, Cracow, Poland,
autor Zima, A.
  • AGH – University of Science and Technology, Cracow, Poland
autor Paszkiewicz, Z.
  • AGH – University of Science and Technology, Cracow, Poland
autor Ślósarczyk, A.
  • AGH – University of Science and Technology, Cracow, Poland
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